Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Introduction on Translational Autoimmunity: From Bench to Bedside Publisher



Rezaei N1, 2, 3 ; Yazdanpanah N4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Iran
  2. 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Iran
  3. 3. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Translational Autoimmunity: Etiology of Autoimmune Diseases Published:2021


Abstract

The immune system is a potent complex system playing a crucial role in human existence. Immune-based diseases vary from an inborn defect in the immune system, which results in primary immunodeficiency, to an overactivation of the immune system, which turns into hypersensitivity states or malfunctions of the immune system in selfdiscrimination and nonselfdiscrimination, which ends in autoimmune diseases. In this chapter, autoimmune diseases are discussed from different points of view with a translational approach. Recent advances and discoveries in the field of immunology thoroughly highlight the significance of translational studies to apply the data from scientific investigations to clinical settings and patient care. Considering the huge burden of autoimmune diseases on patients, families, health care system, and society, applying translational research to optimize the current diagnostic tools and therapeutic strategies or to find out promising alternatives is of interest. © 2022 Elsevier Inc. All rights reserved.