Introduction on Autoimmunity and Associated Conditions Publisher



Rezaei N^{1, 2, 3} ; Yazdanpanah N^{1, 3, 4}
Source: Translational Autoimmunity: Autoimmune Disease Associated with Different Clinical Features Published:2022

Abstract

Autoimmunity has been reported in association with a broad spectrum of conditions. With regard to the burden imparted by autoimmune diseases on patients and the healthcare system due to the chronic nature of the disease, the absence of a definite cure, and the potential comorbidities, associated conditions with autoimmunity are of high significance and should be studied. For instance, autoimmune manifestations have been reported in infections, genetic syndromes, inborn errors of immunity (IEI), malignancies, metabolic disorders, and other medical conditions that could potentially affect patients’ quality of life (QoL). Indeed, the association of autoimmunity in most of these conditions has been proved to be bidirectional, since autoimmunity could lead to development of majority of these conditions, while autoimmune manifestations could develop in the context of the aforementioned conditions as well. © 2022 Elsevier Inc. All rights reserved.