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Innate Lymphoid Cell Subsets and Their Cytokines in Autoimmune Diseases Publisher Pubmed



Maleki A1 ; Khanmiri JM1 ; Eshrat Abadi MK1 ; Soveyzi F2 ; Moazzami B3, 4 ; Hamblin MR5, 6 ; Rezaei N3, 4, 7
Authors
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Authors Affiliations
  1. 1. Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Science, 62 Qarib St, Keshavarz Blvd, Tehran, 14194, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, Johannesburg, 2028, South Africa
  6. 6. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Johannesburg, 2028, South Africa
  7. 7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: European Cytokine Network Published:2020


Abstract

Both the innate and adaptive arms of the immune system are involved in the development of autoimmune diseases. The main mechanism of disease is due to adaptive immune cells that are active against self-antigens. These cells can cause major damage to body tissues. Innate lymphoid cells (ILCs) are an important type of innate immune cell, whose role has been highlighted in recent years. ILCs are responsible for some of the inflammation in the pathogenesis of autoimmune diseases. In this review, we discuss the role of ILCs in the immune response, as well as their involvement in various autoimmune diseases. © 2020, JLE/Springer.