Regenerative Medicine Applications in Wound Care Publisher Pubmed



Nilforoushzadeh MA¹ ; Sisakht MM^{1, 2, 6} ; Seifalian AM³ ; Amirkhani MA¹ ; Banafshe HR² ; Verdi J^{2, 4} ; Sharifzad F^{2, 5} ; Taghiabadi E¹ Show Affiliations
Source: Current Stem Cell Research and Therapy Published:2017

Abstract

Background: During the last two decades, a number of studies have been carried out on the application of regenerative medicine in the field of dermatology. Objective: The aim of this research was to critically review the application of regenerative medicine in the field of dermatology. The next aim was to look in depth to see whether regenerative medicine strategies have a place in the future of wound healing in a clinical setting. More specifically, to see if these strategies would apply for burns and non-healing diabetic wounds. Results: Billions of dollars have been spent worldwide on research in wound treatment and skin regen-eration. Although a high number of clinical trials show promising results, there is still no commercially available treatment for use. In addition, the outcome data from the clinical trials, taking place through-out the world, are not published in a standardized manner. Standardization within clinical trials is required for: protocols, outcome, endpoint values, and length of follow-up. The lack of standardization makes it much more difficult to compare the data collected and the different types of treatment. Conclusion: Despite several promising results from research and early phase clinical studies, the treatment for wounds as well as skin regeneration is still considered as an unmet clinical need. However, in the past three years, more promising research has been approaching clinical trials; this could be the solution that clinicians have been waiting for. This is a multibillion dollar industry for which there should be enough incentive for researchers and industry to seek the solution. © 2017 Bentham Science Publishers.