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Promotion of Excisional Wound Repair by a Menstrual Blood-Derived Stem Cell-Seeded Decellularized Human Amniotic Membrane Publisher



Farzamfar S1 ; Salehi M2, 3 ; Ehterami A2 ; Naserinosar M3 ; Vaez A1 ; Zarnani AH4, 5 ; Sahrapeyma H6 ; Shokri MR7 ; Aleahmad M4
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  4. 4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  6. 6. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Biomedical Engineering Letters Published:2018


Abstract

This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 104 cells/cm2 and implanted onto a rat’s 1.50 × 1.50 cm2 full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries. © 2018, Korean Society of Medical and Biological Engineering and Springer-Verlag GmbH Germany, part of Springer Nature.
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