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Overview of Silk Fibroin Use in Wound Dressings Publisher Pubmed



Farokhi M1 ; Mottaghitalab F2 ; Fatahi Y3 ; Khademhosseini A4 ; Kaplan DL5
Authors
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Authors Affiliations
  1. 1. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of pharmaceutical nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Bioengineering, Department of Chemical and Biomolecular Engineering, Department of Radiology, California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA, United States
  5. 5. Department of Biomedical Engineering, Tufts University, Medford, MA, United States

Source: Trends in Biotechnology Published:2018


Abstract

Recently, biomimetic wound dressings were introduced as potential replacements for treating skin injuries. Although there are some clinically available skin replacements, the range of wound types and locations necessitates a broader range of options for the clinic. Natural polymeric-based dressings are of central interest in this area due to their outstanding biocompatibility, biodegradability, low toxicity, and non-allergenic nature. Among them, silk fibroin (SF) has exceptional characteristics as a wound dressing. SF-based dressings can also be used as carriers for delivering drugs, growth factors, and bioactive agents to the wound area, while providing appropriate support for complete healing. In this review, we describe recent advances in the development of SF-based wound dressings for skin regeneration. © 2018 Elsevier Ltd
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