Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses

Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses Publisher

Nekounam H¹ ; Malakootikhah J² ; Shaterabadi D³ ; Negahdari B⁴ ; Kandi MR³ ; Hamblin MR⁵

Show Affiliations

1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran
3. Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran
4. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Laser Research Centre, University of Johannesburg, Doornfontein, South Africa

Source: Silicon Published:2023

Abstract

Many advances have been made in the preparation, optimization, and applications of silica nanoparticles (NPs) in biomedical nanotechnology. Considering this, the broader human, environmental, and industrial contacts with these NPs are inevitable. Improved knowledge of the physicochemical properties of silica NPs and their interactions with biological systems at the cellular level is essential for the rational design of silica NPs. This can involve the deliberately enhanced or decreased cellular responses and toxicity. Therefore, controlling the risk of toxicity can better guide the design of silica NPs for drug delivery and bioimaging systems. Various reports have discussed the toxicology of silica NPs. However, the mechanisms underlying the cellular responses to these NPs remain unclear. Here, we discuss the physicochemical-biological interactions governing the cellular responses and toxicity of silica NPs. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).

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Style	Citing Format
MLA	Nekounam H, et al.. "Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses." Silicon, vol. 15, no. 13, 2023, pp. 5455-5465.
APA	Nekounam H, Malakootikhah J, Shaterabadi D, Negahdari B, Kandi MR, Hamblin MR (2023). Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses. Silicon, 15(13), 5455-5465.
Chicago	Nekounam H, Malakootikhah J, Shaterabadi D, Negahdari B, Kandi MR, Hamblin MR. "Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses." Silicon 15, no. 13 (2023): 5455-5465.
Harvard	Nekounam H et al. (2023) 'Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses', Silicon, 15(13), pp. 5455-5465.
Vancouver	Nekounam H, Malakootikhah J, Shaterabadi D, Negahdari B, Kandi MR, Hamblin MR. Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses. Silicon. 2023;15(13):5455-5465.
BibTex	@article{ author = {Nekounam H and Malakootikhah J and Shaterabadi D and Negahdari B and Kandi MR and Hamblin MR}, title = {Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses}, journal = {Silicon}, volume = {15}, number = {13}, pages = {5455-5465}, year = {2023} }
RIS	TY - JOUR AU - Nekounam H AU - Malakootikhah J AU - Shaterabadi D AU - Negahdari B AU - Kandi MR AU - Hamblin MR TI - Silica Nps–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses JO - Silicon VL - 15 IS - 13 SP - 5455 EP - 5465 PY - 2023 ER -

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