Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System

Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System Publisher Pubmed

Alizadeh B¹ ; Bahari Javan N¹ ; Akbari Javar H¹ ; Khoshayand MR² ; Dorkoosh F^{1, 3}

Show Affiliations

1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
2. Department of Drug and Food Control and Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
3. Medical Biomaterial Research Center (MBRC), Tehran University of Medical Science, Tehran, Iran

Source: Pharmaceutical Development and Technology Published:2018

Abstract

The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin-poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin-loaded PHBV NPs were prepared via double emulsion solvent evaporation technique. Box–Behnken Response Surface Methodology was utilized to optimize NPs. Mean particle size, polydispersity index (PDI), entrapment efficiency (EE), and drug loading (DL) of the optimized NPs were measured. Incorporation of Nafarelin within NPs was proven by differential scanning calorimetry (DSC). The combination delivery system (CDS) was prepared by adding Nafarelin-loaded PHBV NPs to sodium alginate/poloxamer 407 solution followed by physical mixing. Morphological properties of Nafarelin-loaded PHBV NPs and CDS were evaluated by SEM. Rheological properties were employed to investigate the effects of alginate concentration on sol–gel transition temperature. The release profile of Nafarelin from both PHBV NPs and CDS were individually assessed. The cumulative release percentage from CDS was significantly lower than Nafarelin released from PHBV NPs. Based on the favorable results in this study, the CDS consisting of sodium alginate/poloxamer 407 loaded with PHBV NPs could be a promising candidate for designing a long-lasting formulation of Nafarelin. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

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Farid Dorkoosh (7)

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Style	Citing Format
MLA	Alizadeh B, et al.. "Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System." Pharmaceutical Development and Technology, vol. 23, no. 2, 2018, pp. 132-144.
APA	Alizadeh B, Bahari Javan N, Akbari Javar H, Khoshayand MR, Dorkoosh F (2018). Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System. Pharmaceutical Development and Technology, 23(2), 132-144.
Chicago	Alizadeh B, Bahari Javan N, Akbari Javar H, Khoshayand MR, Dorkoosh F. "Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System." Pharmaceutical Development and Technology 23, no. 2 (2018): 132-144.
Harvard	Alizadeh B et al. (2018) 'Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System', Pharmaceutical Development and Technology, 23(2), pp. 132-144.
Vancouver	Alizadeh B, Bahari Javan N, Akbari Javar H, Khoshayand MR, Dorkoosh F. Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System. Pharmaceutical Development and Technology. 2018;23(2):132-144.
BibTex	@article{ author = {Alizadeh B and Bahari Javan N and Akbari Javar H and Khoshayand MR and Dorkoosh F}, title = {Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System}, journal = {Pharmaceutical Development and Technology}, volume = {23}, number = {2}, pages = {132-144}, year = {2018} }
RIS	TY - JOUR AU - Alizadeh B AU - Bahari Javan N AU - Akbari Javar H AU - Khoshayand MR AU - Dorkoosh F TI - Prolonged Injectable Formulation of Nafarelin Using in Situ Gel Combination Delivery System JO - Pharmaceutical Development and Technology VL - 23 IS - 2 SP - 132 EP - 144 PY - 2018 ER -

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