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Preparation, Statistical Optimisation and in Vitro Characterisation of Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate)/Poly (Lactic-Co-Glycolic Acid) Blend Nanoparticles for Prolonged Delivery of Teriparatide Publisher



Bahari Javan N1 ; Rezaie Shirmard L1 ; Jafary Omid N1 ; Akbari Javar H1 ; Rafiee Tehrani M1 ; Abedin Dorkoosh F1
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Authors Affiliations
  1. 1. Faculty of Pharmacy, Department of Pharmaceutics, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Microencapsulation Published:2016


Abstract

The purpose of this study was the preparation, optimisation and in vitro characterisation of PHBV and PLGA blend nanoparticles (NPs) for prolonged delivery of Teriparatide. Double emulsion solvent evaporation technique was employed for the fabrication of NPs. The nanoformulation was optimised using the Box–Behnken methodology. The morphological properties of NPs were assessed by both SEM and transmission electron microscopy (TEM). Encapsulation of Teriparatide within the NPs and lacking of chemical bonds between drug and copolymers were proved by XRPD, FTIR and DSC. The structural stability of Teriparatide after processing was confirmed by fluorescence spectrometry. The average size of optimised NPs was 250.0 nm with entrapment efficiency (EE) of 89.5% and drug loading (DL) of 5.0%. Teriparatide release from optimised NPs led to 64.4% release over 30 days and it showed a diffusion-based mechanism. Based on the favourable results, PHBV/PLGA blend NPs could be a promising candidate for designing a controlled release formulation of Teriparatide. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
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