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Brain Mri Findings in Neurologically Symptomatic Covid-19 Patients: A Systematic Review and Meta-Analysis Publisher Pubmed



Afsahi AM1 ; Norbash AM1 ; Syed SF2 ; Sedaghat M4 ; Afsahi G5 ; Shahidi R6 ; Tajabadi Z7 ; Bagherzadehfard M8 ; Karami S9 ; Yarahmadi P9 ; Shirdel S10 ; Asgarzadeh A11 ; Baradaran M12 ; Khalaj F7 Show All Authors
Authors
  1. Afsahi AM1
  2. Norbash AM1
  3. Syed SF2
  4. Sedaghat M4
  5. Afsahi G5
  6. Shahidi R6
  7. Tajabadi Z7
  8. Bagherzadehfard M8
  9. Karami S9
  10. Yarahmadi P9
  11. Shirdel S10
  12. Asgarzadeh A11
  13. Baradaran M12
  14. Khalaj F7
  15. Sadeghsalehi H13
  16. Fotouhi M14
  17. Habibi MA8
  18. Jang H1
  19. Alavi A15
  20. Sedaghat S1, 3
Show Affiliations
Authors Affiliations
  1. 1. Department of Radiology, University of California, San Diego, CA, United States
  2. 2. Department of Radiology, Weill Cornell Medicine, New York, NY, United States
  3. 3. Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany
  4. 4. Department for Radiology and Neuroradiology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
  5. 5. Department of Biotechnology Research, Blue California Ingredients, Rancho Santa Margarita, CA, United States
  6. 6. School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  7. 7. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Qom University of Medical Sciences, Qom, Iran
  9. 9. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Psychology, Faculty of Education and Psychology, University of Tabriz, Tabriz, Iran
  11. 11. Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  12. 12. Department of Radiology, Imam Ali Hospital, North Khorasan University of Medical Science, Bojnurd, Iran
  13. 13. Department of Artificial Intelligence in Medical Sciences, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  14. 14. Quantitative MR Imaging and Spectroscopy Group (QMISG), Research Centre for Molecular and Cellular Imaging (RCMCI), Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences (TUMS), Tehran, Iran
  15. 15. Department of Diagnostic Radiology and Nuclear Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Source: Journal of Neurology Published:2023


Abstract

Background: Coronavirus disease 2019 (COVID-19) has been associated with nervous system involvement, with more than one-third of COVID-19 patients experiencing neurological manifestations. Utilizing a systematic review, this study aims to summarize brain MRI findings in COVID-19 patients presenting with neurological symptoms. Methods: Systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) checklist. The electronic databases of PubMed/MEDLINE, Embase, Scopus, and Web of Science were systematically searched for literature addressing brain MRI findings in COVID-19 patients with neurological symptoms. Results: 25 publications containing a total number of 3118 COVID-19 patients with neurological symptoms who underwent MRI were included. The most common MRI findings and the respective pooled incidences in decreasing order were acute/subacute infarct (22%), olfactory bulb abnormalities (22%), white matter abnormalities (20%), cerebral microbleeds (17%), grey matter abnormalities (12%), leptomeningeal enhancement (10%), ADEM (Acute Disseminated Encephalomyelitis) or ADEM-like lesions (10%), non-traumatic ICH (10%), cranial neuropathy (8%), cortical gray matter signal changes compatible with encephalitis (8%), basal ganglia abnormalities (5%), PRES (Posterior Reversible Encephalopathy Syndrome) (3%), hypoxic-ischemic lesions (4%), venous thrombosis (2%), and cytotoxic lesions of the corpus callosum (2%). Conclusion: The present study revealed that a considerable proportion of patients with COVID-19 might harbor neurological abnormalities detectable by MRI. Among various findings, the most common MRI alterations are acute/subacute infarction, olfactory bulb abnormalities, white matter abnormalities, and cerebral microbleeds. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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