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Nanoparticles in the Regulation of Autophagy for Cancer Therapy Publisher



M Hashemi MEHRDAD ; P Rahimzadeh PAYMAN ; V Tavakolpour VAHID ; Sk Zomorrodian Seyedeh KIMIA ; Me Vaghar Mohammad ESLAMI ; Sv Arasi Saba VAZIRBANI ; F Atabi FERESHTEH ; B Jamali BEHDOKHT ; K Shahpasand KOUROSH ; N Farahani NAJMA
Authors

Source: Published:2025


Abstract

The management of cancer necessitates the use of innovative and advanced techniques that ensure precise targeting of tumor cells. Presently, the methods employed for cancer suppression face challenges due to inadequate targeting capabilities. Furthermore, even with gene therapy, there’s a risk of degradation in the bloodstream, highlighting the necessity for encapsulation and protection. This chapter delves into how nanoparticles regulate autophagy in cancer treatment. It examines the ways nanostructures can either stress the autophagy regulation or transport chemotherapy drugs and other regulatory elements to influence autophagy, thereby aiding in cancer suppression, remodeling the tumor microenvironment (TME), and enhancing the sensitivity to therapy. © 2025 Elsevier B.V., All rights reserved.
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