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For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy Publisher



Karimi S1 ; Bakhshali R2 ; Bolandi S3 ; Zahed Z4 ; Mojtaba Zadeh SS5 ; Kaveh Zenjanab M6 ; Jahanban Esfahlan R6
Authors
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Authors Affiliations
  1. 1. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Omid Cancer Center, Ahvaz, Iran
  3. 3. Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran
  5. 5. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical, Sciences, Tehran, Iran
  6. 6. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Materials Today Bio Published:2025


Abstract

Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive and innovative perspective on how nanomedicine can modify the TME to enhance therapy. Strategies include using nanoparticles to improve oxygenation, adjust acidity, and alter the extracellular matrix, making treatments more effective. Additionally, nanoparticles can enhance immune responses by activating immune cells and reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy and radiotherapy, nanoparticles show promise in overcoming traditional treatment barriers. The review discusses how changes in the TME can enhance the effectiveness of nanomedicine itself, creating a reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting and overcoming the TME, leveraging nanoparticle-based approaches for targeted cancer therapy through precise TME modulation. © 2025
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