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Nanostructure-Reinforced Multifunctional Hydrogels for Synergistic Cancer Therapy Publisher



Yousefiasl S1 ; Ghovvati M2 ; Mirshafiei M3 ; Hakimi F4 ; Azadi A5 ; Moezzi SMI6 ; Yuan M7, 8 ; Sefat F9, 10 ; Zare I11 ; Maleki A12 ; Lin J7, 8
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Department of Radiological Sciences, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, 90095, CA, United States
  3. 3. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  4. 4. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  5. 5. Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China
  8. 8. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China
  9. 9. Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford, United Kingdom
  10. 10. Interdisciplinary Research Centre in Polymer Science & Technology (Polymer IRC), University of Bradford, Bradford, United Kingdom
  11. 11. Research and Development Department, Sina Medical Biochemistry Technologies Co., Ltd., Shiraz, 7178795844, Iran
  12. 12. Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), and Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139-56184, Iran

Source: Coordination Chemistry Reviews Published:2025


Abstract

Hydrogel-integrated nanostructures offer a novel approach to cancer therapy by combining hydrogels' biocompatibility and tunable drug release with nanotechnology. These nanoplatforms enhance treatment precision and efficacy while minimizing side effects, providing a sophisticated and targeted delivery system. This comprehensive review explores synergistic cancer therapies utilizing hydrogel-integrated nanoplatforms, which employ dual strategies to enhance their anticancer efficacy. These strategies include chemodynamic therapy (CDT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy, radiotherapy (RT), gene therapy (GT), and magnetic hyperthermia therapy (MHT). Such platforms have the potential to overcome multidrug-resistant cancers, pioneer innovative treatment modalities, and improve patient survival rates compared to monotherapies. However, challenges such as scalability, regulatory approval, optimizing drug release kinetics, and addressing potential toxicity concerns remain, which are critical for assessing their long-term effects and clinical applicability. © 2024 Elsevier B.V.
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