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Assessment of Benzene Induced Oxidative Impairment in Rat Isolated Pancreatic Islets and Effect on Insulin Secretion Publisher Pubmed



Bahadar H1 ; Maqbool F1 ; Mostafalou S2 ; Baeeri M1 ; Rahimifard M3 ; Navaeinigjeh M3 ; Abdollahi M1, 3
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  2. 2. School of Pharmacy, Ardebil University of Medical Sciences, Ardebil, Iran
  3. 3. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Environmental Toxicology and Pharmacology Published:2015


Abstract

Benzene (C6H6) is an organic compound used in petrochemicals and numerous other industries. It is abundantly released to our environment as a chemical pollutant causing widespread human exposure. This study mainly focused on benzene induced toxicity on rat pancreatic islets with respect to oxidative damage, insulin secretion and glucokinase (GK) activity. Benzene was dissolved in corn oil and administered orally at doses 200, 400 and 800mg/kg/day, for 4 weeks. In rats, benzene significantly raised the concentration of plasma insulin. Also the effect of benzene on the release of glucose-induced insulin was pronounced in isolated islets. Benzene caused oxidative DNA damage and lipid peroxidation, and also reduced the cell viability and total thiols groups, in the islets of exposed rats.In conclusion, the current study revealed that pancreatic glucose metabolism is susceptible to benzene toxicity and the resultant oxidative stress could lead to functional abnormalities in the pancreas. © 2015 Elsevier B.V.
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