The Role of Notch Signaling in Bone Marrow Niche

The Role of Notch Signaling in Bone Marrow Niche Publisher Pubmed

Azizidoost S¹ ; Shanaki Bavarsad M² ; Shanaki Bavarsad M² ; Shahrabi S³ ; Jaseb K¹ ; Rahim F⁴ ; Shahjahani M⁵ ; Saba F⁵ ; Ghorbani M⁶ ; Saki N¹

Show Affiliations

1. Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Clinical Biochemistry Department, Tehran University of Medical Science, Tehran, Iran
3. Department of Biochemistry and Hematology, Semnan University of Medical Sciences, Semnan, Iran
4. Health Research Institute, Hearing Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5. Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
6. Department of Laboratory Science, AJA University of Medical Sciences, Tehran, Iran

Source: Hematology Published:2015

Abstract

Objective: Bone marrow (BM) niche is a three-dimensional structure composed of a series of cells and it is one of the most controversial topics in hematological malignancies, leukemia, and even metastasis. Here, we review the relationship between Notch signaling and different fates of stem cells and other BM niche cells. Methods: Relevant English-language literaturewere searched and retrieved from PubMed (2000–2013) using the terms Notch signaling, BM niche, and microRNAs (miRNAs). Discussion: Notch signaling pathway is a signaling system involved in cellular processes such as proliferation, differentiation, and apoptosis. The notch signaling pathway components are associated with interaction between leukemic, metastatic, and normal cells and their microenvironment. miRNAs play an important role in expression and regulation of signaling molecules. It is necessary to evaluate the elationship between aberrant miRNA expression and notch signaling such as miR-128 and miR-30 in glioma and angiogenesis with notch signaling, respectively. Conclusions: Characterizing malignant cells and future studies focus on better understanding the variety of cancers and apoptosis with activated Notch signaling pathway, may remain promising this signaling system as a safe and effective therapeutic target. © W. S. Maney & Son Ltd 2015.

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Style	Citing Format
MLA	Azizidoost S, et al.. "The Role of Notch Signaling in Bone Marrow Niche." Hematology, vol. 20, no. 2, 2015, pp. 93-103.
APA	Azizidoost S, Shanaki Bavarsad M, Shanaki Bavarsad M, Shahrabi S, Jaseb K, Rahim F, Shahjahani M, Saba F, Ghorbani M, Saki N (2015). The Role of Notch Signaling in Bone Marrow Niche. Hematology, 20(2), 93-103.
Chicago	Azizidoost S, Shanaki Bavarsad M, Shanaki Bavarsad M, Shahrabi S, Jaseb K, Rahim F, Shahjahani M, Saba F, Ghorbani M, Saki N. "The Role of Notch Signaling in Bone Marrow Niche." Hematology 20, no. 2 (2015): 93-103.
Harvard	Azizidoost S et al. (2015) 'The Role of Notch Signaling in Bone Marrow Niche', Hematology, 20(2), pp. 93-103.
Vancouver	Azizidoost S, Shanaki Bavarsad M, Shanaki Bavarsad M, Shahrabi S, Jaseb K, Rahim F, et al.. The Role of Notch Signaling in Bone Marrow Niche. Hematology. 2015;20(2):93-103.
BibTex	@article{ author = {Azizidoost S and Shanaki Bavarsad M and Shanaki Bavarsad M and Shahrabi S and Jaseb K and Rahim F and Shahjahani M and Saba F and Ghorbani M and Saki N}, title = {The Role of Notch Signaling in Bone Marrow Niche}, journal = {Hematology}, volume = {20}, number = {2}, pages = {93-103}, year = {2015} }
RIS	TY - JOUR AU - Azizidoost S AU - Shanaki Bavarsad M AU - Shanaki Bavarsad M AU - Shahrabi S AU - Jaseb K AU - Rahim F AU - Shahjahani M AU - Saba F AU - Ghorbani M AU - Saki N TI - The Role of Notch Signaling in Bone Marrow Niche JO - Hematology VL - 20 IS - 2 SP - 93 EP - 103 PY - 2015 ER -

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