An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer

An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer Publisher

Amirinejad R¹ ; Rezaei M² ; Shirvanifarsani Z²

Show Affiliations

1. Genetics Department, Breast Cancer Research Center, Motamed Center Institute, ACECR, Tehran, Iran
2. Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C, Tehran, Iran

Source: Cell and Bioscience Published:2020

Abstract

Long intergenic noncoding RNA p21 was mapped on the human chromosome 6p21.2. Accordingly, it was firstly described by promoting the p53-dependent apoptosis in the mouse. Also, it is a new lncRNA playing some vital roles in the cell cycle, apoptosis, cell proliferation, tumorigenesis, invasion, metastasis, and angiogenesis. In this regard, it was shown that, lincRNA-p21 regulates these biological processes involved in carcinogenesis through various signaling pathways including Notch signaling, JAK2/STAT3, and AKT/mTOR pathways. Another mechanism by that lincRNA-p21 can affect these processes is a cross-talk with different miRNAs. In vitro and in vivo studies revealed dysregulation of lincRNA-p21 in various human cancers. In addition, emerging evidence demonstrated that, lincRNA-p21 can be considered as a potential prognostic and therapeutic biomarker in cancers. Also, lincRNA-p21 enhances the response to radiotherapy for colorectal cancer. However, the molecular mechanisms of lincRNA-p21 in carcinogenesis have not been fully elucidated so far. So, this review summarizes the function of lincRNA-p21, as a tumor suppressor factor in different biological processes implicated in cancers. © 2020 The Author(s).

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Hamid Reza Mirzaei (2)

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Style	Citing Format
MLA	Amirinejad R, Rezaei M, Shirvanifarsani Z. "An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer." Cell and Bioscience, vol. 10, no. 1, 2020, pp. -.
APA	Amirinejad R, Rezaei M, Shirvanifarsani Z (2020). An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer. Cell and Bioscience, 10(1), -.
Chicago	Amirinejad R, Rezaei M, Shirvanifarsani Z. "An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer." Cell and Bioscience 10, no. 1 (2020): -.
Harvard	Amirinejad R, Rezaei M, Shirvanifarsani Z (2020) 'An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer', Cell and Bioscience, 10(1), pp. -.
Vancouver	Amirinejad R, Rezaei M, Shirvanifarsani Z. An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer. Cell and Bioscience. 2020;10(1):-.
BibTex	@article{ author = {Amirinejad R and Rezaei M and Shirvanifarsani Z}, title = {An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer}, journal = {Cell and Bioscience}, volume = {10}, number = {1}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Amirinejad R AU - Rezaei M AU - Shirvanifarsani Z TI - An Update on Long Intergenic Noncoding Rna P21: A Regulatory Molecule With Various Significant Functions in Cancer JO - Cell and Bioscience VL - 10 IS - 1 SP - EP - PY - 2020 ER -

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