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Encapsulation of the Phmb With Nanoliposome and Attachment to Wound Dressing for Long-Term Antibacterial Activity and Biocompatibility Publisher Pubmed



Ahani E1 ; Montazer M2, 3 ; Mianehro A3 ; Samadi N4 ; Toliyat T5 ; Rad MM6
Authors
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Authors Affiliations
  1. 1. Azad University, Science and Research Unit, Tehran, Iran
  2. 2. Functional Fibrous Structures & Environmental Enhancement (FFSEE), Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran
  3. 3. Textile Department, Amirkabir University of Technology, 424 Hafez Ave, Tehran, 15875-4413, Iran
  4. 4. Department of Drug and Food Control, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Phytochemistry Research Center, Shahid Beheshti Medical Sciences, Tehran, Iran

Source: World Journal of Microbiology and Biotechnology Published:2024


Abstract

Concentration control of some drug are used commonly however their uncontrolled concentration renders severe side effects. Therefore, it is substantial to come up with innovation release control methods. There is a strong affinity between the phospholipid of nanoliposomes and wool cells which facilitate the diffusion of liposomes into the wool structure. On the other hand, polyhexamethylene biguanide (PHMB) has gained popularity as an antibacterial agent; however, the compound’s cytotoxicity has limited its usefulness. By compounding these facts, this work introduces a novel method for sustained drug release via internalization. In this method, PHMB was detained into nanoliposomes infiltrated the wool to generate an extremely regulated release, which was established using various techniques. SEM pictures demonstrated effective absorption of nanoliposome-encapsulated PHMB within the wool fabric. The developed wound dressing showed a sustained drug release, and consequently, perfect biocompatibility and enduring antibacterial activity. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Nature B.V. 2024.
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1. Preparation of Long-Lasting Antibacterial Wound Dressing Through Diffusion of Cationic-Liposome-Encapsulated Polyhexamethylene Biguanide, Reactive and Functional Polymers (2021)
2. A Novel Biocompatible Antibacterial Product: Nanoliposomes Loaded With Poly(Hexamethylene Biguanide Chloride), Journal of Bioactive and Compatible Polymers (2017)
3. Preparation of Nano Cationic Liposome As Carrier Membrane for Polyhexamethylene Biguanide Chloride Through Various Methods Utilizing Higher Antibacterial Activities With Low Cell Toxicity, Journal of Microencapsulation (2017)
Experts (# of related papers)
Tayebeh Toliyat (3)
Nasrin Samadi (1)