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Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and Biomems Publisher



Farahani A1 ; Zareihanzaki A2 ; Abedi HR3 ; Daryoush S1 ; Ragheb ZD3 ; Mianabadi F4 ; Shahparvar S2 ; Akrami M5 ; Mostafavi E6, 7 ; Khanbareh H8 ; Nezami FR9
Authors
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Authors Affiliations
  1. 1. Department of Materials Science and Engineering, Pennsylvania State University, University Park, 16802, PA, United States
  2. 2. Hot Deformation and Thermomechanical Processing Laboratory of High-Performance Engineering Materials, School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran
  3. 3. School of Metallurgy and Materials Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
  4. 4. Department of Petroleum and Chemical Engineering, Sharif University of Technology, Tehran, Iran
  5. 5. Department of Pharmaceutical Biomaterials, and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, United States
  7. 7. Department of Medicine, Stanford University School of Medicine, Stanford, 94305, CA, United States
  8. 8. Department of Mechanical Engineering, University of Bath, Calverton Down, Bath, BA2 7AY, United Kingdom
  9. 9. Division of Thoracic and Cardiac Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, 02115, MA, United States

Source: Journal of Polymers and the Environment Published:2023


Abstract

As an FDA-approved biopolymer, silk has been contemplated for a wide range of applications based on its unique merits, such as biocompatibility, biodegradability, and piezoelectricity. As silk, in both crystalline structure and amorphous state, exhibits unique physical, mechanical, and biological properties (promoting cell migration, differentiation, growth, and protein-surface interaction), it is fruitful to understand its potential applications. Sensors, actuators, and drug delivery systems are the best in case. As such, the current effort first introduces silk fibroin (SF) and delineates its characteristics. It then explores the extensive use of this biomaterial in tissue engineering approaches, in addition to its biosensor and electro-active wearable bioelectronic application. To this end, the SF application in cardiovascular, skin, cartilage, and drug delivery systems for cancer therapy and wound healing was studied precisely. Compositing any type of other variables to induce a specific application or improve any SF barriers, namely its hydrophobicity, poor electrical conductivity, or tuning its mechanical properties, especially in tissue engineering applications, has also been discussed wherever it is deemed informative. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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