Preparation of Long-Lasting Antibacterial Wound Dressing Through Diffusion of Cationic-Liposome-Encapsulated Polyhexamethylene Biguanide Publisher



Ahani E¹ ; Montazer M² ; Mianehro A² ; Samadi N³ ; Toliyat T⁴ ; Mahmoudi Rad M⁵
Source: Reactive and Functional Polymers Published:2021

Abstract

Polyhexamethylene biguanide (PHMB) has been used increasingly in various applications because of antibacterial properties; however, its cytotoxicity hampers application. On the other hand, there is a high affinity between the cell membrane complexes (CMCs) in wool structure and phospholipids of cationic nanoliposomes, leading to the transmission of cationic nanoliposomes into the wool. In this research, a novel method for PHMB controlled release is introduced by combining these facts. Firstly, PHMB was encapsulated into cationic liposome and then permeated into the wool to establish a highly controlled release then characterized through diverse methods. SEM images revealed successful transmission of cationic-liposome-encapsulated PHMB into the wool. The prepared wound dressings demonstrated highly sustained release for days and subsequently, long-term perfect antibacterial activity and biocompatibility. © 2021 Elsevier B.V.