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Recent Trends in Controlled Drug Delivery Based on Silk Platforms Publisher



Shirangi A1 ; Sepehr A2 ; Kundu SC3 ; Moradi A1 ; Farokhi M4 ; Mottaghitalab F1
Authors
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Authors Affiliations
  1. 1. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. 3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimaraes, Portugal
  4. 4. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran

Source: Silk-Based Biomaterials for Tissue Engineering# Regenerative# and Precision Medicine# 2nd Edition Published:2023


Abstract

Silk biomaterials are reputed as potential platforms for biomedical applications due to their unique characteristics, such as excellent biocompatibility, biodegradation rate, mechanical strength, and less immunogenicity. Silk materials can be prepared in different structures like nanoparticles, hydrogels, nanofibers, films, and sponges using methods such as desolvation, freeze-drying, self-assembly, electrospinning, and others. Here, different silk platforms for drug delivery applications are reviewed. The advantages and disadvantages of each system are described in detail. Silk-based constructs are introduced as powerful delivery platforms for various drugs and biomolecules for diagnostic and therapeutic purposes. © 2024 Elsevier Ltd. All rights reserved.
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