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Recent Advances in Fluorescence Nanoparticles “Quantum Dots” As Gene Delivery System: A Review Publisher Pubmed



Zahed Z1 ; Hadi R2 ; Imanzadeh G2 ; Ahmadian Z3 ; Shafiei S4 ; Zadeh AZ5 ; Karimi H6 ; Akbarzadeh A7 ; Abbaszadeh M8 ; Ghadimi LS9 ; Kafil HS8 ; Kazeminava F10
Authors
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Authors Affiliations
  1. 1. Department of Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran
  2. 2. Department of Chemistry, Faculty of Basic Science, University of Mohaghegh Ardabili, Ardabil, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. Yasuj University of Medical Science, Yasuj, Iran
  5. 5. Ahvaz University of Medical Science, Ahvaz, Iran
  6. 6. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Electrical and Computer Engineering, Queen's University, Kingston, K7L 3N6, ON, Canada
  10. 10. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: International Journal of Biological Macromolecules Published:2024


Abstract

Biomaterial scientists have recently focused their attention on evaluating various aspects of delivering genetic materials into cells to induce a cellular response. The process involves complexing negatively charged plasmids, followed by delivering the resulting package into cells, a process facilitated by lipids, peptides, viruses, synthetically modified cationic polymers, and specific inorganic nanomaterials. In the context of gene delivery for specific imaging in biological and biomedical applications, fluorescence nanocrystals or quantum dots (QDs) present promising candidates as engineered nanoparticles (NPs). This literature review study aims to investigate the potential of QDs as a novel tool for gene delivery to retinal cells. The proficiency of QDs in this context arises from their unique physicochemical characteristics, including optical electronic and catalytic properties, which render them viable options for biosensing imaging, drug delivery, and gene delivery applications. In the field of gene delivery to the retinal cells, factors such as photoluminescence, quantum yield, biocompatibility, size, and shape play crucial roles in the utilization of QDs. In this paper, we discuss the most appropriate credentials and briefly outline the findings, supported by relevant illustrative samples, to explore the delivery of genetic material utilizing QDs. © 2023 Elsevier B.V.
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