Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression

Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression Publisher Pubmed

Yadegari A¹ ; Khezri J² ; Esfandiari S² ; Mahdavi H³ ; Karkhane AA² ; Rahighi R^{4, 7} ; Heidarimoghadam R⁵ ; Tayebi L¹ ; Hashemi E^{2, 8} ; Farmany A⁶

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1. School of Dentistry, Marquette University, Milwaukee, 53233, WI, United States
2. National Research Center for Transgenic Mouse National Institute of Genetic Engineering and Biotechnology, P.O. Box, Tehran, 14965-161, Iran
3. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
4. Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
5. Department of Ergonomics, Faculty of Health and Medical Sciences Research Centre, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
6. Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
7. Department of Research and Development, Sharif Ultrahigh Nanotechnologists (SUN) Company, P.O. Box: 13488-96394, Tehran, Iran
8. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Colloids and Surfaces B: Biointerfaces Published:2019

Abstract

In this paper, a bottom-up hydrothermal route is reported for the synthesis of oxygen and nitrogen co-decorated carbon quantum dots (CQDs) using ammonium hydrogen citrate (AHC) as a single precursor. DLS data approved the formation of 4.0 nm (average size) CQDs. XRD pattern shows the interlayer spacing (002) of 3.5 A for CQDs, which is exactly the same as that of crystalline graphite. XPS and FTIR spectra verified the formation of oxygen and nitrogen functional groups on the CQDs surface. Co-decorated carboxyl, hydroxyl and amine groups on the CQDs surfaces make them as promising polyelectrolyte for gene delivery. Toxicity assay showed a survival rate of 70% under different incubation times and up to 500 μg/mL. The highly water-soluble, stable fluorescence and low toxic CQDs increased the gene expression of DNA plasmid in E. coli bacteria 4-fold more than the control group. © 2019 Elsevier B.V.

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Style	Citing Format
MLA	Yadegari A, et al.. "Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression." Colloids and Surfaces B: Biointerfaces, vol. 184, no. , 2019, pp. -.
APA	Yadegari A, Khezri J, Esfandiari S, Mahdavi H, Karkhane AA, Rahighi R, Heidarimoghadam R, Tayebi L, Hashemi E, Farmany A (2019). Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression. Colloids and Surfaces B: Biointerfaces, 184(), -.
Chicago	Yadegari A, Khezri J, Esfandiari S, Mahdavi H, Karkhane AA, Rahighi R, Heidarimoghadam R, Tayebi L, Hashemi E, Farmany A. "Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression." Colloids and Surfaces B: Biointerfaces 184, no. (2019): -.
Harvard	Yadegari A et al. (2019) 'Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression', Colloids and Surfaces B: Biointerfaces, 184(), pp. -.
Vancouver	Yadegari A, Khezri J, Esfandiari S, Mahdavi H, Karkhane AA, Rahighi R, et al.. Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression. Colloids and Surfaces B: Biointerfaces. 2019;184():-.
BibTex	@article{ author = {Yadegari A and Khezri J and Esfandiari S and Mahdavi H and Karkhane AA and Rahighi R and Heidarimoghadam R and Tayebi L and Hashemi E and Farmany A}, title = {Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression}, journal = {Colloids and Surfaces B: Biointerfaces}, volume = {184}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Yadegari A AU - Khezri J AU - Esfandiari S AU - Mahdavi H AU - Karkhane AA AU - Rahighi R AU - Heidarimoghadam R AU - Tayebi L AU - Hashemi E AU - Farmany A TI - Bottom-Up Synthesis of Nitrogen and Oxygen Co-Decorated Carbon Quantum Dots With Enhanced Dna Plasmid Expression JO - Colloids and Surfaces B: Biointerfaces VL - 184 IS - SP - EP - PY - 2019 ER -

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