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Rifampicin Resistance in Mycobacterium Tuberculosis in Iran: A Two-Centre Study Publisher



Bahraminia F1 ; Zangiabadian M2 ; Nasiri MJ3 ; Fattahi M4 ; Goudarzi M3 ; Ranjbar R5 ; Imani Fooladi AA1
Authors
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Authors Affiliations
  1. 1. Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Regional Tuberculosis Reference Laboratory, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: New Microbes and New Infections Published:2021


Abstract

Multidrug-resistant tuberculosis remains a challenge. In this study, we investigated the incidence of rifampicin (RIF) resistance in Mycobacterium tuberculosis in a large number of pulmonary specimens. A two-center study in Tehran, the capital of Iran, was performed with 6624 pulmonary samples of patients with tuberculosis (TB) who were subjected to detection of RIF-resistant TB by GeneXpert MTB/RIF assay between May 2014 and July 2018. Conventional drug susceptibility testing was performed to confirm the results. Xpert MTB/RIF identified a total of 96 positives for M. tuberculosis, of which 5 (5.3%) samples were found to be RIF-resistant TB. All RIF-resistant and sensitive isolates detected by GeneXpert were phenotypically confirmed by drug susceptibility testing. These results indicated that the Xpert MTB/RIF test can be used as a rapid diagnostic method and can potentially decrease the morbidity associated with diagnostic delay and mistreatment. © 2021 The Authors
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