Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis

Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis Publisher Pubmed

Behniafard N^{1, 2} ; Amirzargar AA^{3, 4} ; Gharagozlou M¹ ; Delavari F^{2, 5} ; Hosseinverdi S² ; Sotoudeh S¹ ; Farhadi E⁶ ; Mahmoudi M^{7, 8} ; Khaledi M⁹ ; Moghaddam ZG¹ ; Aghamohammadi A^{1, 2} ; Rezaei N^{2, 3, 10}

Show Affiliations

1. Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
6. Hematology Department, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, Iran
7. School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
8. Dietitians and Nutrition Expert Team (DiNET), Universal Scientific Education and Research Network (USERN), Tehran, Iran
9. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
10. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, United States

Source: Allergologia et Immunopathologia Published:2018

Abstract

Background: Atopic dermatitis is an inflammatory skin disease in which both genetic and environmental factors interact to determine the susceptibility and severity of the disease. Objective: The aim of this study was to determine the association between atopic dermatitis and IL-10 and TGF-β1 gene polymorphisms. Methods: The allele and genotype frequencies of genes encoding for IL-10 and TGF-β1 were investigated in 89 patients with atopic dermatitis in comparison with 138 in the control group using the PCR-SSP method. Results: A significant increase was found in the frequency of the TGF-β1 codon 10/C allele among patients (p < 0.001, OR = 6.77), whereas a significant decrease was observed in the frequency of the T allele at the same position (p < 0.001, OR = 0.14). The frequency of the TGF-β1 codon 25/G allele in the control group was significantly higher than among patients (p < 0.001, OR = 0.08). A significant positive correlation was seen between CC (p < 0.001, OR = 15.10) and CG (p < 0.001) genotypes and AD at codons 10 and 25, respectively. The most frequent haplotypes among patients was TGF-β1 CG which was significantly higher than in the control subjects (50% in patients vs. 39.9% in controls, p = 0.042). A significant increase was found in the frequency of TGF-β CC (36% in patients vs. 7.6% in controls, p < 0.001) and TC (14% in patients vs. 0% in controls, p < 0.001) haplotypes among patients compared to controls. By contrast, the TGF-β1 TG haplotype was significantly lower in patients than controls (0% in patients vs. 52.5% in controls, p < 0.001). There were no significant differences in the frequency of alleles, genotypes and haplotypes of the IL-10 gene. Conclusions: We found a strong association between the polymorphisms of the TGF-β1 gene at codon 10 and codon 25 positions and atopic dermatitis. © 2017 SEICAP

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Style	Citing Format
MLA	Behniafard N, et al.. "Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis." Allergologia et Immunopathologia, vol. 46, no. 2, 2018, pp. 155-159.
APA	Behniafard N, Amirzargar AA, Gharagozlou M, Delavari F, Hosseinverdi S, Sotoudeh S, Farhadi E, Mahmoudi M, Khaledi M, Moghaddam ZG, Aghamohammadi A, Rezaei N (2018). Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis. Allergologia et Immunopathologia, 46(2), 155-159.
Chicago	Behniafard N, Amirzargar AA, Gharagozlou M, Delavari F, Hosseinverdi S, Sotoudeh S, Farhadi E, et al.. "Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis." Allergologia et Immunopathologia 46, no. 2 (2018): 155-159.
Harvard	Behniafard N et al. (2018) 'Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis', Allergologia et Immunopathologia, 46(2), pp. 155-159.
Vancouver	Behniafard N, Amirzargar AA, Gharagozlou M, Delavari F, Hosseinverdi S, Sotoudeh S, et al.. Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis. Allergologia et Immunopathologia. 2018;46(2):155-159.
BibTex	@article{ author = {Behniafard N and Amirzargar AA and Gharagozlou M and Delavari F and Hosseinverdi S and Sotoudeh S and Farhadi E and Mahmoudi M and Khaledi M and Moghaddam ZG and Aghamohammadi A and Rezaei N}, title = {Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis}, journal = {Allergologia et Immunopathologia}, volume = {46}, number = {2}, pages = {155-159}, year = {2018} }
RIS	TY - JOUR AU - Behniafard N AU - Amirzargar AA AU - Gharagozlou M AU - Delavari F AU - Hosseinverdi S AU - Sotoudeh S AU - Farhadi E AU - Mahmoudi M AU - Khaledi M AU - Moghaddam ZG AU - Aghamohammadi A AU - Rezaei N TI - Single Nucleotide Polymorphisms of the Genes Encoding Il-10 and Tgf-Β1 in Iranian Children With Atopic Dermatitis JO - Allergologia et Immunopathologia VL - 46 IS - 2 SP - 155 EP - 159 PY - 2018 ER -

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