Type 2 Diabetes Mellitus and Alzheimer's Disease: A Review of the Potential Links Publisher Pubmed



Pakdin M¹ ; Toutounchian S² ; Namazi S² ; Arabpour Z³ ; Pouladi A⁴ ; Afsahi S² ; Poudineh M⁵ ; Nasab MMM⁴ ; Yaghoobpoor S⁴ ; Deravi N⁴ Show Affiliations
Source: Current Diabetes Reviews Published:2022

Abstract

Diabetes mellitus and Alzheimer’s disease are considered the most prevalent diseases in older ages worldwide. The main pathology of Alzheimer’s disease is highly related with accumula¬tion of misfolded proteins that lead to neuronal dysfunction in the brain. On the other hand, dia¬betes mellitus is associated with alteration of insulin signaling, which could cause the reduction of glucose uptake, metabolic prohibition of energy consuming cells, as well as suppression of glucose to fat conversion in the liver. In spite of having seemingly different pathological features, both dis¬eases share common underlying biological mechanisms. Besides, the epidemiological and environ¬mental links between these two diseases should not be overlooked. In this study, we aim to review shared pathological mechanisms of Alzheimer’s disease and diabetes mellitus, including impaired glucose metabolism, increased Amyloid-Beta (AP) production, impaired lipid metabolism, mito¬chondrial dysfunction, increased inflammation and elevated oxidative stress. Furthermore, we dis¬cuss epidemiological association between these two diseases and also review animal investigations, which have evaluated the potential links between the two diseases. © 2022 Bentham Science Publishers.