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The Potential of Mitochondrial Modulation by Neuroglobin in Treatment of Neurological Disorders Publisher Pubmed



Gorabi AM1 ; Aslani S2 ; Barreto GE3, 4 ; Baezjurado E5 ; Kiaie N1 ; Jamialahmadi T6, 7 ; Sahebkar A8, 9, 10, 11
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biological Sciences, University of Limerick, Limerick, Ireland
  4. 4. Health Research Institute, University of Limerick, Limerick, Ireland
  5. 5. Departamento de Quimica, Facultad de Ciencias, Universidad Antonio Narino, Bogota D.C., Colombia
  6. 6. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran
  7. 7. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
  11. 11. Halal Research Center of IRI, FDA, Tehran, Iran

Source: Free Radical Biology and Medicine Published:2021


Abstract

Neuroglobin is the third member of the globin family to be identified in 2000 in neurons of both human and mouse nervous systems. Neuroglobin is an oxygen-binding globin found in neurons within the central nervous system as well as in peripheral neurons, that produces a protective effect against hypoxic/ischemic damage induced by promoting oxygen availability within the mitochondria. Numerous investigations have demonstrated that impaired neuroglobin functioning is implicated in the pathogenesis of multiple neurodegenerative disorders. Several in vitro and animal studies have reported the potential of neuroglobin upregulation in improving the neuroprotection through modulation of mitochondrial functions, such as ATP production, clearing reactive oxygen species (ROS), promoting the dynamics of mitochondria, and controlling apoptosis. Neuroglobin acts as a stress-inducible globin, which has been associated hypoxic/ischemic insults where it acts to protect the heart and brain, providing a wide range of applicability in the treatment of human disorders. This review article discusses normal physiological functions of neuroglobin in mitochondria-associated pathways, as well as outlining how dysregulation of neuroglobin is associated with the pathogenesis of neurodegenerative disorders. © 2020 Elsevier Inc.
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