Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target

Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target Publisher Pubmed

Mousaviniri N¹ ; Naseroleslami M² ; Hadjati J³

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1. Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2. Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Human Vaccines and Immunotherapeutics Published:2019

Abstract

Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment. The main members of suppressive milieu of tumor are heteroogenous groups of immune cells in which regulatory T cell is a substantial component. Tregs express different immunomodulatory molecules such as FoxP3. Transcription factor, FoxP3, is a specific intracellular marker of Treg and crucial for Treg development. Therefore it is an attractive target for cancer treatment. This article reviews some recent anti-Treg vaccine focusing on FoxP3 to ameliorate anti-tumor immune responses. Among them, fusion vaccine of FoxP3-Fc(IgG) recombinant DNA vaccine and its accordant protein vaccine represents effective results. © 2019, © 2019 Taylor & Francis Group, LLC.

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Jamshid Hadjati (4)

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Style	Citing Format
MLA	Mousaviniri N, Naseroleslami M, Hadjati J. "Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target." Human Vaccines and Immunotherapeutics, vol. 15, no. 3, 2019, pp. 620-624.
APA	Mousaviniri N, Naseroleslami M, Hadjati J (2019). Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target. Human Vaccines and Immunotherapeutics, 15(3), 620-624.
Chicago	Mousaviniri N, Naseroleslami M, Hadjati J. "Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target." Human Vaccines and Immunotherapeutics 15, no. 3 (2019): 620-624.
Harvard	Mousaviniri N, Naseroleslami M, Hadjati J (2019) 'Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target', Human Vaccines and Immunotherapeutics, 15(3), pp. 620-624.
Vancouver	Mousaviniri N, Naseroleslami M, Hadjati J. Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target. Human Vaccines and Immunotherapeutics. 2019;15(3):620-624.
BibTex	@article{ author = {Mousaviniri N and Naseroleslami M and Hadjati J}, title = {Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target}, journal = {Human Vaccines and Immunotherapeutics}, volume = {15}, number = {3}, pages = {620-624}, year = {2019} }
RIS	TY - JOUR AU - Mousaviniri N AU - Naseroleslami M AU - Hadjati J TI - Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target JO - Human Vaccines and Immunotherapeutics VL - 15 IS - 3 SP - 620 EP - 624 PY - 2019 ER -

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