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Study of the Cardioprotective Effects of Crocin on Human Cardiac Myocyte Cells and Reduction of Oxidative Stress Produced by Aluminum Phosphide Poisoning Publisher Pubmed



Naddafi M2, 3 ; Eghbal MA1, 2 ; Ghazikhansari M4 ; Sattari MR2 ; Azarmi Y2
Authors
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Authors Affiliations
  1. 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Pharmacology and Toxicology Department, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Pharmacy and Pharmacology Published:2021


Abstract

ObjectivesThe effects of Crocin as a cardioprotective material against Aluminum phosphide poisoning by reducing the oxidative stress is investigated. Methods The level of biomarkers of oxidative stress (Catalase, Superoxide dismutase, Malondialdehyde and Protein carbonyl) were measured in the cell culture model on Human Cardiac Myocyte cells to detect the protective effect of crocin. Initially, to define the pure impact of aluminum phosphide poison and crocin on the heart cells, their effects on the biomarkers quantity in cell line were measured, separately, using the standard related kits. Later the effect of crocin with different concentration as a treatment on the oxidative stress biomarkers of the poisoned heart cells were monitored. Note that in pre-treatment case, the crocin was initially added to the cells before poisoning them. Data were analyzed using the analysis of variance method. Key findings Results showed that crocin treatment reduced the aluminum phosphide (AlP) poisoning effect significantly. The treatment resulted in substantial deviation in the biomarkers of oxidative stress at the pre- and post-treatment phases for all groups.The oxidative markers values of the poisoned cells were recovered by crocin treatment. Conclusions Crocin is proposed as a potentially powerful antioxidant to treat the cardiotoxicity caused by aluminum phosphide poisoning. © The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved.
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