Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population

Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population Publisher Pubmed

Bahrami T¹ ; Soltani S² ; Moazzami K^{3, 4} ; Yekaninejad MS⁵ ; Salmaninejad A⁶ ; Soltaninejad E⁷ ; Ziaee V^{8, 9} ; Rezaei N^{10, 11, 12}

Show Affiliations

1. Genetics Research Center (GRC), Department of Medical Genetics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
2. Molecular Immunology Research Center, Tehran University of Medical Sciences, School of Medicine, Tehran, Iran
3. Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, United States
5. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences School of Medicine, Tehran, Iran
6. Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran
7. Department of Immunology, Birjand University of Medical Sciences, Birjand, Iran
8. Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
9. Division of Pediatric Rheumatology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
10. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
11. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
12. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, United Kingdom

Source: Fetal and Pediatric Pathology Published:2017

Abstract

Juvenile idiopathic arthritis (JIA), the most common cause of chronic arthritis in children, is a complex immune-mediated disease with considerable long-term morbidity and mortality. According to previous studies, PTPN22 gene has been associated with JIA in several populations. In the present study, we attempted to determine the association of PTPN22 single nucleotide polymorphisms (SNPs) with susceptibility to JIA in Iranian population. Using the Real-time PCR allelic discrimination method, samples consisting of 55 unrelated patients and 93 healthy controls were genotyped. Using Fisher exact test or Chi-square test, genotypic and allelic frequencies were estimated. The results of our study indicated a significantly decreased association of rs1310182 (OR = 0.59, 95% CI = 0.36 −0.97, p = 0.037) with JIA. This association may indicate a protective role for rs1310182 SNP against JIA. More research would be needed to elucidate the mechanistic role of this association. © 2017 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Bahrami T, et al.. "Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population." Fetal and Pediatric Pathology, vol. 36, no. 1, 2017, pp. 42-48.
APA	Bahrami T, Soltani S, Moazzami K, Yekaninejad MS, Salmaninejad A, Soltaninejad E, Ziaee V, Rezaei N (2017). Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population. Fetal and Pediatric Pathology, 36(1), 42-48.
Chicago	Bahrami T, Soltani S, Moazzami K, Yekaninejad MS, Salmaninejad A, Soltaninejad E, Ziaee V, Rezaei N. "Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population." Fetal and Pediatric Pathology 36, no. 1 (2017): 42-48.
Harvard	Bahrami T et al. (2017) 'Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population', Fetal and Pediatric Pathology, 36(1), pp. 42-48.
Vancouver	Bahrami T, Soltani S, Moazzami K, Yekaninejad MS, Salmaninejad A, Soltaninejad E, et al.. Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population. Fetal and Pediatric Pathology. 2017;36(1):42-48.
BibTex	@article{ author = {Bahrami T and Soltani S and Moazzami K and Yekaninejad MS and Salmaninejad A and Soltaninejad E and Ziaee V and Rezaei N}, title = {Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population}, journal = {Fetal and Pediatric Pathology}, volume = {36}, number = {1}, pages = {42-48}, year = {2017} }
RIS	TY - JOUR AU - Bahrami T AU - Soltani S AU - Moazzami K AU - Yekaninejad MS AU - Salmaninejad A AU - Soltaninejad E AU - Ziaee V AU - Rezaei N TI - Association of Ptpn22 Gene Polymorphisms With Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population JO - Fetal and Pediatric Pathology VL - 36 IS - 1 SP - 42 EP - 48 PY - 2017 ER -

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