Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Methylomics of Breast Cancer: Seeking Epimarkers in Peripheral Blood of Young Subjects Publisher Pubmed



Khakpour G1 ; Noruzinia M2 ; Izadi P1 ; Karami F3 ; Ahmadvand M4 ; Heshmat R5 ; Amoli MM6 ; Tavakkolybazzaz J1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Medical Genetics, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Chronic Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Tumor Biology Published:2017


Abstract

Critical roles of epigenomic alterations in the pathogenesis of breast cancer have recently seized great attentions toward finding epimarkers in either non-invasive or semi-non-invasive samples as well as peripheral blood. In this way, methylated DNA immunoprecipitation microarray (MeDIP-chip) was performed on DNA samples isolated from white blood cells of 30 breast cancer patients compared to 30 healthy controls. A total of 1799 differentially methylated regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant methylation differences were confirmed in breast cancer patients through quantitative real-time polymerase chain reaction. Hypermethylation of APC, HDAC1, and GSK1 genes has been previously reported in more than one study on tissue samples of breast cancer. Methylation of those aforementioned genes in white blood cells of our young patients not only relies on their importance in breast cancer pathogenesis but also may highlight their potential as early epimarkers that makes further assessments necessary in large cohort studies. © 2017, © The Author(s) 2017.
Related Docs
View other Related Docs
1. Dna Methylation As a Promising Landscape: A Simple Blood Test for Breast Cancer Prediction, Tumor Biology (2015)
2. Epigenetics and Three Main Clinical Aspects of Breast Cancer Management, Epigenetics Territory and Cancer (2015)
3. Potential Use of Dok7 Gene Methylation Level in the Peripheral Blood Cells As a Biomarker in Early Diagnosis of Sporadic Breast Cancer, Genetics in the Third Millennium (2016)
4. Young Breast Cancer: Novel Gene Methylation in Wbc, Asian Pacific Journal of Cancer Prevention (2021)
5. Tusc3 Methylation in Peripheral Blood Cells As a Biomarker for Diagnosis of Colorectal Cancer, Advanced Biomedical Research (2023)
6. Cancer Genetics at a Glance: The Comprehensive Insights, Cancer Genetics and Psychotherapy (2017)
7. Association of Folate and Other One-Carbon Related Nutrients With Hypermethylation Status and Expression of Rarb, Brca1, and Rassf1a Genes in Breast Cancer Patients, Journal of Molecular Medicine (2015)
8. Methylation in Colorectal Cancer, Epigenetics Territory and Cancer (2015)
Experts (# of related papers)
View all Related Experts
Pantea Izadi (2)
Mohammad Hossein Modarressi (1)
Other Related Docs
9. Evaluation of the Epigenetic Demethylation of Nrf2, a Master Transcription Factor for Antioxidant Enzymes, in Colorectal Cancer, Reports of Biochemistry and Molecular Biology (2020)
10. Liquid Biopsy in Female Genital Tract (Ovarian Cancer, Endometrial Tumor, and Cervical Tumor), Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)