The Effects of Nano-Curcumin Supplementation on Adipokines Levels in Obese and Overweight Patients With Migraine: A Double Blind Clinical Trial Study Publisher Pubmed



Sedighiyan M¹ ; Abdolahi M² ; Jafari E³ ; Vahabi Z^{4, 5} ; Sohrabi Athar S⁶ ; Hadavi S⁷ ; Narimani Zamanabadi M⁸ ; Yekaninejad MS⁹ ; Djalali M¹ Show Affiliations
Source: BMC Research Notes Published:2022

Abstract

Objective: The present study aimed to investigate the effects of nano-curcumin supplementation on adipokines levels and clinical signs in obese and overweight patients with migraine. Results: Forty-four patients with episodic migraine participated in this clinical trial and were divided into two groups nano-curcumin (80 mg/day) and the control group over 2-month period. At the baseline and the end of the research, the serum levels of MCP-1, Resistin, and Visfatin were measured using the ELISA method. In addition, the headache attack frequencies, severity, and duration of pain were recorded. The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). In the case of resistin and visfatin, nano-curcumin supplementation exerted no statistically significant changes in serum levels (P > 0.05). Nano-curcumin also significantly reduced the attack frequencies, severity, and duration of headaches (P < 0.05). These findings indicate that targeting curcumin can be a promising approach to migraine management. However, further comprehensive human trials are needed to confirm these findings. Trial Registration: This study was registered in the Iranian Registry of Clinical Trials (IRCT) with ID number: IRCT20160626028637N2 on the date 2020-07-10. © 2022, The Author(s).