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The Effects of Nano-Curcumin Supplementation on Leptin and Adiponectin in Migraine Patients: A Double-Blind Clinical Trial Study From Gene Expression to Clinical Symptoms Publisher Pubmed



Sedighiyan M1 ; Jafari E2 ; Athar SS3 ; Yekaninejad MS4 ; Alvandi E5 ; Abdolahi M6 ; Djalali M1
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran
  2. 2. Headache Research Center, Sina Hospital, Tehran University of Medical Sciences, Imam Khomeini Street, Tehran, Iran
  3. 3. Department of Human Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Resalat Street, Urmia, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Western Sydney University, Campbelltown, 2560, NSW, Australia
  6. 6. Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Sa'adi Street, Tehran, Iran

Source: Endocrine# Metabolic and Immune Disorders - Drug Targets Published:2023


Abstract

Background: Migraine is a disabling neurogenic disorder characterized by recurrent headache attacks. Adipokines act as inflammatory and pain mediators that contribute to migraine pathogenesis. Leptin and adiponectin levels change in migraine patients and are associated with headache attacks. Curcumin can exert modulatory and analgesic effects on adipokines through several mechanisms, from gene expression to suppressing pain. The aim of the present study was to evaluate the effects of nano-curcumin supplementation on leptin and adiponectin gene expres-sion, their serum levels and migraine symptoms in patients with migraine. Methods: Forty-four episodic migraine patients enrolled in this trial were divided into two groups as nano-curcumin (80 mg/day) and placebo group, over a two-month period. At the beginning and the end of the study, the mRNA expression of leptin and adiponectin from isolated PBMCs and their serum levels were measured using real-time PCR and ELISA method, respectively. The headache frequencies, severity and duration of pain were also recorded. Results: The results of the present research showed that nano-curcumin can up-regulate adi-ponectin mRNA and increase its serum level significantly (P < 0.05). In the case of leptin, a re-duction in gene expression and concentration was found in the nano-curcumin group but it was not statistically significant (P > 0.05). Nano-curcumin also significantly reduced the frequency, severity and duration of headaches (P < 0.05). Conclusion: These findings indicate that nano-curcumin supplement can be considered as a promising approach to migraine management and clinical symptoms improvement. © 2023 Bentham Science Publishers.
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