The Omega-3 and Nano-Curcumin Effects on Vascular Cell Adhesion Molecule (Vcam) in Episodic Migraine Patients: A Randomized Clinical Trial Publisher Pubmed



Abdolahi M¹ ; Karimi E² ; Sarraf P^{3, 4} ; Tafakhori A^{3, 4} ; Siri G⁵ ; Salehinia F⁵ ; Sedighiyan M⁶ ; Asanjarani B⁵ ; Badeli M⁷ ; Abdollahi H⁸ ; Yoosefi N⁹ ; Yousefi A⁸ ; Rad AS⁶ ; Djalali M⁶ Show Affiliations
Source: BMC Research Notes Published:2021

Abstract

Objective: The purpose of this clinical trial was to examine the effect of omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of VCAM in patients with episodic migraine. Results: In this study, 80 patients were randomly divided in to 4 groups to receive for 2 months. Both serum levels and gene expression of VCAM showed remarkable decreases after single W-3 and after combined W-3 and nanocurcumin interventions. However, a borderline significant change and no remarkable change were observed after single nanocurcumin supplementation and in control group, respectively. While a significant difference between study groups in VCAM concentrations existed, there was no meaningful difference in VCAM gene expression among groups. It appears that the W-3 and combined W-3 and nanocurcumin can relieve VCAM serum level and its gene expression in patients with episodic migraine. Moreover, the combination of W-3 with nanocurcumin might cause more significant declines in VCAM level in the serum of migraine patients than when W-3 is administered alone. Trial Registration: This study was registered in Iranian Registry of Clinical Trials (IRCT) with ID number: NCT02532023. © 2021, The Author(s).