Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Gut Microbiota-Brain Axis in Pathophysiology of Adhd: A Systematic Review Publisher Pubmed



Shirvanirad S1, 2 ; Ejtahed HS1 ; Ettehad Marvasti F1 ; Taghavi M1 ; Sharifi F1 ; Arzaghi SM1 ; Larijani B1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Journal of Attention Disorders Published:2022


Abstract

Objective: The main goal of this systematic review is to summarize evidences regarding alterations of microbial composition in ADHD cases and uncover underlying mechanisms. Methods: A comprehensive search was conducted on PubMed, Web of Science, and Scopus databases up to March 2021. All the observational studies including case-control, cross-sectional, and cohorts investigating the correlations between the gut microbiota and ADHD in both adults and children were included. Results: We found eight eligible studies. Enterococcus, Bifidobacterium, and Odoribacter were increased which may lead to impaired dopamine related functions in CNS. Moreover, decrease of Faecalibacterium frequency in ADHD could result in higher permeability and crossing of inflammatory cytokines. Regarding the short chain fatty acids-producing bacteria, Ruminococcaceae family decreased and Bacteroides uniformis and Bacteroides ovatus species increased. Conclusion: Gut microbiota correlation with ADHD and its underlying mechanisms could open new windows for developing novel therapies of ADHD by manipulating microbiota. © ©The Author(s) 2022.
Related Docs
View other Related Docs
1. Effect of Nutritional Supplements on Gut Microbiome in Individuals With Neurodevelopmental Disorders: A Systematic Review and Narrative Synthesis, BMC Nutrition (2025)
2. Targeting Pi3k by Natural Products: A Potential Therapeutic Strategy for Attention-Deficit Hyperactivity Disorder, Current Neuropharmacology (2022)
3. Gut Microbiota: A Perspective of Precision Medicine in Endocrine Disorders, Journal of Diabetes and Metabolic Disorders (2020)
4. The Microbiome in Precision Medicine: A New Approach to Cancer Treatment, Journal of Mazandaran University of Medical Sciences (2021)
5. Shedding Light on Biological Sex Differences and Microbiota–Gut–Brain Axis: A Comprehensive Review of Its Roles in Neuropsychiatric Disorders, Biology of Sex Differences (2022)
6. Is There Any Link Between Cognitive Impairment and Gut Microbiota? a Systematic Review, Gerontology (2022)
7. Gut Microbiota Modulation As a Possible Mediating Mechanism for Fasting-Induced Alleviation of Metabolic Complications: A Systematic Review, Nutrition and Metabolism (2021)
8. Gut Microbiota Composition in Obese and Normal Weight Adults in Iran, Journal of Mazandaran University of Medical Sciences (2021)
Experts (# of related papers)
View all Related Experts
Hanieh-Sadat Ejtahed (23)
Bagher Larijani (21)
Other Related Docs
9. Microbiota Research in Iran; Current Knowledge and Future Perspective, Journal of Diabetes and Metabolic Disorders (2021)
10. Multidimensional Perspective of Obesity; Prevention to Treatment, Journal of Diabetes and Metabolic Disorders (2021)
11. Precision Medicine in Endocrinology Practice, Precision Medicine in Clinical Practice (2022)
12. Role of Microbiota-Derived Short-Chain Fatty Acids in Nervous System Disorders, Biomedicine and Pharmacotherapy (2021)
13. The Second Brain: The Connection Between Gut Microbiota Composition and Multiple Sclerosis, Journal of Neuroimmunology (2021)
14. Targeting Obesity Management Through Gut Microbiota Modulation by Herbal Products: A Systematic Review, Complementary Therapies in Medicine (2019)
15. The Mental Health of Healthcare Workers in the Covid-19 Pandemic: A Systematic Review, Journal of Diabetes and Metabolic Disorders (2020)
16. Ethical Challenges in Conducting and the Clinical Application of Human Microbiome Research, Journal of Medical Ethics and History of Medicine (2023)
17. Herbal Medicines in the Treatment of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (Adhd): An Updated Systematic Review of Clinical Trials, Avicenna Journal of Phytomedicine (2023)
18. Gut Microbiota-Derived Metabolites in Obesity: A Systematic Review, Bioscience of Microbiota# Food and Health (2020)
19. Neuromodulatory Effect of Microbiome on Gut-Brain Axis; New Target for Obesity Drugs, Journal of Diabetes and Metabolic Disorders (2019)
20. Our Little Friends With Big Roles: Alterations of the Gut Microbiota in Thyroid Disorders, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
21. Probiotic Supplement As an Adjunctive Therapy With Ritalin for Treatment of Attention-Deficit Hyperactivity Disorder Symptoms in Children: A Double-Blind Placebo-Controlled Randomized Clinical Trial, Nutrition and Food Science (2023)
22. Metformin Induces Weight Loss Associated With Gut Microbiota Alteration in Non-Diabetic Obese Women: A Randomized Double-Blind Clinical Trial, European Journal of Endocrinology (2019)
23. Main Gut Bacterial Composition Differs Between Patients With Type 1 and Type 2 Diabetes and Non-Diabetic Adults, Journal of Diabetes and Metabolic Disorders (2020)
24. Adaptation of Human Gut Microbiota to Bariatric Surgeries in Morbidly Obese Patients: A Systematic Review, Microbial Pathogenesis (2018)
25. Clinical Application of Gut Microbiota Metabolites: A Novel Opportunity in Personalized Medicine, Koomesh (2022)
26. Exploring the Role of Gut Microbiota Dysbiosis in Gout Pathogenesis: A Systematic Review, Frontiers in Medicine (2023)
27. Efficacy, Safety, and Tolerability of Serotonin-Norepinephrine Reuptake Inhibitors in Controlling Adhd Symptoms: A Systematic Review and Meta-Analysis, Middle East Current Psychiatry (2024)
28. The Effects of Probiotics, Prebiotics, and Synbiotics on Polycystic Ovarian Syndrome: An Overview of Systematic Reviews, Frontiers in Medicine (2023)
29. The Role of Intestinal Microbiota in Cognitive Disorders, Journal of Mazandaran University of Medical Sciences (2021)
30. Probiotics As a New Regulator for Bone Health: A Systematic Review and Meta-Analysis, Evidence-based Complementary and Alternative Medicine (2021)
31. Probiotics Supplementation for the Obesity Management; a Systematic Review of Animal Studies and Clinical Trials, Journal of Functional Foods (2019)
32. Trimethylamine N-Oxide As a Potential Risk Factor for Non-Communicable Diseases: A Systematic Review, Endocrine# Metabolic and Immune Disorders - Drug Targets (2023)
33. Worldwide Trends in Scientific Publications on Association of Gut Microbiota With Obesity, Iranian Journal of Basic Medical Sciences (2019)
34. The Critical Role of Faecalibacterium Prausnitzii in Human Health: An Overview, Microbial Pathogenesis (2020)