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Phage Therapy As a Glimmer of Hope in the Fight Against the Recurrence or Emergence of Surgical Site Bacterial Infections Publisher Pubmed



Moghadam MT1 ; Mojtahedi A2 ; Salamy S3 ; Shahbazi R4 ; Satarzadeh N5, 6 ; Delavar M7 ; Ashoobi MT8
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
  4. 4. Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Student Research Committee, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Vice President of Health and Executive Vice President, Rey Health Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran

Source: Infection Published:2024


Abstract

Purpose: Over the last decade, surgery rates have risen alarmingly, and surgical-site infections are expanding these concerns. In spite of advances in infection control practices, surgical infections continue to be a significant cause of death, prolonged hospitalization, and morbidity. As well as the presence of bacterial infections and their antibiotic resistance, biofilm formation is one of the challenges in the treatment of surgical wounds. Methods: This review article was based on published studies on inpatients and laboratory animals receiving phage therapy for surgical wounds, phage therapy for tissue and bone infections treated with surgery to prevent recurrence, antibiotic-resistant wound infections treated with phage therapy, and biofilm-involved surgical wounds treated with phage therapy which were searched without date restrictions. Results: It has been shown in this review article that phage therapy can be used to treat surgical-site infections in patients and animals, eliminate biofilms at the surgical site, prevent infection recurrence in wounds that have been operated on, and eradicate antibiotic-resistant infections in surgical wounds, including multi-drug resistance (MDR), extensively drug resistance (XDR), and pan-drug resistance (PDR). A cocktail of phages and antibiotics can also reduce surgical-site infections more effectively than phages alone. Conclusion: In light of these encouraging results, clinical trials and research with phages will continue in the near future to treat surgical-site infections, biofilm removal, and antibiotic-resistant wounds, all of which could be used to prescribe phages as an alternative to antibiotics. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2024.
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