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Improving Hemocompatibility in Tissue-Engineered Products Employing Heparin-Loaded Nanoplatforms Publisher Pubmed



Beheshtizadeh N1, 12 ; Mohammadzadeh M2, 12 ; Mostafavi M3 ; Seraji AA4, 5 ; Esmaeili Ranjbar F6, 12 ; Tabatabaei SZ7 ; Ghafelehbashi R8, 9, 12 ; Afzali M10, 12 ; Lolasi F11, 12
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  3. 3. Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
  5. 5. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran
  6. 6. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  7. 7. Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  9. 9. Department of Materials and Textile Engineering, College of Engineering, Razi University, Kermanshah, Iran
  10. 10. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of pharmaceutical biotechnology, Faculty of Pharmacy And Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Regenerative Medicine group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Pharmacological Research Published:2024


Abstract

The enhancement of hemocompatibility through the use of nanoplatforms loaded with heparin represents a highly desirable characteristic in the context of emerging tissue engineering applications. The significance of employing heparin in biological processes is unquestionable, owing to its ability to interact with a diverse range of proteins. It plays a crucial role in numerous biological processes by engaging in interactions with diverse proteins and hydrogels. This review provides a summary of recent endeavors focused on augmenting the hemocompatibility of tissue engineering methods through the utilization of nanoplatforms loaded with heparin. This study also provides a comprehensive review of the various applications of heparin-loaded nanofibers and nanoparticles, as well as the techniques employed for encapsulating heparin within these nanoplatforms. The biological and physical effects resulting from the encapsulation of heparin in nanoplatforms are examined. The potential applications of heparin-based materials in tissue engineering are also discussed, along with future perspectives in this field. © 2024 The Authors
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