Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Advances in Cancer Nanovaccines: A Focus on Colorectal Cancer Publisher Pubmed



Ghazizadeh Y1, 2 ; Salehi Shadkami H2, 3 ; Madani F4 ; Niknam S5 ; Adabi M4, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Nanomedicine Student Association (NMA), Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Science, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Institute of Nano Science and Nano Technology, University of Kashan, Kashan, Iran
  6. 6. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2025


Abstract

Nanotechnology has revolutionized cancer treatment by providing innovative solutions through nanocancer therapies, nanovaccines, and nanoparticles. This review focuses on the application of these technologies in colorectal cancer (CRC), highlighting their progression from preclinical studies to clinical trials. Nanoparticles, including liposomes, silica, gold, and lipid nanoparticles, possess unique properties that enhance drug delivery, improve therapeutic efficacy, and minimize systemic toxicity. Additionally, nanovaccines are being developed to elicit robust immune responses against CRC cells. This paper offers a comprehensive overview of the current state of nanotechnology-based treatments for CRC, emphasizing key preclinical studies and clinical trials that demonstrate their potential. Furthermore, the review discusses the challenges faced in this field. It outlines future directions for research, underscoring the need for ongoing efforts to translate these promising technologies into practical clinical applications. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Nanoimmunoengineering Strategies in Cancer Diagnosis and Therapy, Clinical and Translational Oncology (2023)
2. Nanovaccines for Cancer Immunotherapy: Focusing on Complex Formation Between Adjuvant and Antigen, International Immunopharmacology (2023)
3. Nanomedicine for Improvement of Dendritic Cell-Based Cancer Immunotherapy, International Immunopharmacology (2020)
Experts (# of related papers)
View all Related Experts
Babak Negahdari (3)
Mohammad Hossein Modarressi (2)
Other Related Docs
4. Mrna Cancer Vaccines From Bench to Bedside: A New Era in Cancer Immunotherapy, Biomarker Research (2024)
5. Heterologous Administration of Hpv16 E7 Epitope-Loaded Nanocomplexes Inhibits Tumor Growth in Mouse Model, International Immunopharmacology (2021)
6. Nano-Particles’ Benefits for Colon Cancer Effective Therapy: A Review of Recent Advancements and Clinical Trials, International Journal of Polymeric Materials and Polymeric Biomaterials (2024)
7. Expression Patterns of Cxcl12 and Its Receptor in Colorectal Carcinoma, Clinical Laboratory (2018)
8. Self-Assembling Peptide Epitopes As Novel Platform for Anticancer Vaccination, Molecular Pharmaceutics (2017)
9. Cancer Nanomedicine: Special Focus on Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
10. Evaluation of the Histopathologic Status of Rectal Adenocarcinoma and Its Regional Lymph Nodes After Neoadjuvant Therapy, and Its Relation to the Duration of Disease-Free Survival, Indian Journal of Pathology and Microbiology (2022)
11. Deregulated Expression of Hdac3 in Colorectal Cancer and Its Clinical Significance, Advances in Clinical and Experimental Medicine (2018)
12. Nanoparticles in Cancer Immunotherapies: An Innovative Strategy, Biotechnology Progress (2021)
13. Dna Vaccines As Promising Immuno-Therapeutics Against Cancer: A New Insight, Frontiers in Immunology (2024)
14. The Expression of Glypican-3 in Colorectal Cancer, Cytology and Genetics (2019)
15. A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on Molecular and Biochemical Processes, Cell Biochemistry and Function (2024)
16. Polymeric Nanoparticles for Dna Vaccine-Based Cancer Immunotherapy: A Review, Biotechnology Letters (2023)