Nanofiber-Based Systems Against Skin Cancers: Therapeutic and Protective Approaches Publisher



Maleki H¹ ; Doostan M² ; Shojaei S¹ ; Doostan M² ; Stamatis H³ ; Gkantzou E³ ; Bonkdar A^{4, 5} ; Khoshnevisan K^{4, 5, 6}
Source: Journal of Drug Delivery Science and Technology Published:2023

Abstract

The incidence of skin cancer (SC) has dramatically risen over the last decades. Conventional therapeutic trials possess numerous drawbacks; hence, developing effective therapies is indispensable. Modern delivery systems, e.g., nanofiber-based systems, can deliver therapeutic agents and nanostructures, which could be the harbinger of a new era to obviate SC complications. As a versatile technique, electrospinning (ES) can be applied for nanofibers (NFs) fabrication with natural and synthetic polymers or both. Such structures offer a great number of advantages because of their unique properties so that a delivery system or reservoirs can provide an adequate matrix for encapsulation and incorporation of therapeutic agents such as chemical components and natural substances as well as able to prevent the harmful impact of radiation exposure. In addition, therapeutic nanostructures, e.g., metal and magnetic nanoparticles (NPs), have been incorporated into NFs to achieve multimodal treatments like photo-thermal therapy and hyperthermia. Thus, in this study, the various mentioned nanofibrous-based strategies and their effectiveness in treating SCs have been discussed. © 2023 Elsevier B.V.