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Extracellular Vesicles in Bone and Periodontal Regeneration: Current and Potential Therapeutic Applications Publisher



Gholami L1 ; Nooshabadi VT2, 3 ; Shahabi S4 ; Jazayeri M4 ; Tarzemany R5 ; Afsartala Z6, 7 ; Khorsandi K8
Authors
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Authors Affiliations
  1. 1. Department of Periodontics, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Science, Semnan, Iran
  3. 3. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
  4. 4. Student Research Committee, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, Canada
  6. 6. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran
  7. 7. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Photodynamic, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran

Source: Cell and Bioscience Published:2021


Abstract

Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs’ EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects. © 2021, The Author(s).
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