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Multi-Omics Insights Into Autoimmune Thrombocytopenic Purpura Publisher



Kiumarsi A1
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Hematology–Oncology, Children's Medical Center Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Comprehensive Hematology and Stem Cell Research: Volume 1-5 Published:2024


Abstract

Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder which is characterized by the decrease in platelet quantity and an increase in the risk of bleeding. Complex abnormalities in the cellular and humoral immune systems result in not only enhanced platelet destruction, but also suppression of platelet production process. Recent developments in genomics, epigenomics, transcriptomics, and proteomics have provided new insights to the etiology and treatment of ITP. A deeper understanding about the disease at different molecular and cellular levels could provide better diagnostic and prognostic methods and also aid toward the development of improved and personalized treatment modalities. This review is focused on the multi-omics aspects of ITP pathophysiology with a critical review on the cellular interactions in ITP, and discussing the effect of different therapeutic strategies on the pathogenic mechanisms. © 2024 Elsevier Inc. All rights are reserved.
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