Dysregulated Expression of Mirnas in Immune Thrombocytopenia

Dysregulated Expression of Mirnas in Immune Thrombocytopenia Publisher Pubmed

Jafarzadeh A^{1, 2} ; Marzban H³ ; Nemati M^{4, 5} ; Jafarzadeh S⁶ ; Mahjoubintehran M⁷ ; Hamblin MR⁸ ; Mirzaei H^{9, 10} ; Mirzaei HR¹¹

Show Affiliations

1. Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, 76169-13555, Iran
2. Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, 7718175911, Iran
3. Department of Pathology and Experimental Animals, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, 31975/148, Iran
4. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, 77181/75911, Iran
5. Department of Hematology and Laboratory Sciences, School of Para-Medicine, Kerman University of Medical Sciences, Kerman, 76169-13555, Iran
6. Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, 76169-13555, Iran
7. Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 13131- 99137, Iran
8. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa
9. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, 87159-88141, Iran
10. Student Research Committee, Kashan University of Medical Sciences, Kashan, 87159-88141, Iran
11. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran

Source: Epigenomics Published:2021

Abstract

In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications. © 2021 Future Medicine Ltd.

2. Autoimmune Diseases, Clinical Immunology (2022)

3. Il-22 Produced by T Helper Cell 22 As a New Player in the Pathogenesis of Immune Thrombocytopenia, Endocrine# Metabolic and Immune Disorders - Drug Targets (2015)

4. A Comprehensive Review on Mir-146A Molecular Mechanisms in a Wide Spectrum of Immune and Non-Immune Inflammatory Diseases, Immunology Letters (2020)

5. Primary Immunodeficiency and Thrombocytopenia, International Reviews of Immunology (2022)

Experts (# of related papers)

Nima Rezaei (1)

Sayed Alireza Razavi (1)

Style	Citing Format
MLA	Jafarzadeh A, et al.. "Dysregulated Expression of Mirnas in Immune Thrombocytopenia." Epigenomics, vol. 13, no. 16, 2021, pp. 1315-1325.
APA	Jafarzadeh A, Marzban H, Nemati M, Jafarzadeh S, Mahjoubintehran M, Hamblin MR, Mirzaei H, Mirzaei HR (2021). Dysregulated Expression of Mirnas in Immune Thrombocytopenia. Epigenomics, 13(16), 1315-1325.
Chicago	Jafarzadeh A, Marzban H, Nemati M, Jafarzadeh S, Mahjoubintehran M, Hamblin MR, Mirzaei H, Mirzaei HR. "Dysregulated Expression of Mirnas in Immune Thrombocytopenia." Epigenomics 13, no. 16 (2021): 1315-1325.
Harvard	Jafarzadeh A et al. (2021) 'Dysregulated Expression of Mirnas in Immune Thrombocytopenia', Epigenomics, 13(16), pp. 1315-1325.
Vancouver	Jafarzadeh A, Marzban H, Nemati M, Jafarzadeh S, Mahjoubintehran M, Hamblin MR, et al.. Dysregulated Expression of Mirnas in Immune Thrombocytopenia. Epigenomics. 2021;13(16):1315-1325.
BibTex	@article{ author = {Jafarzadeh A and Marzban H and Nemati M and Jafarzadeh S and Mahjoubintehran M and Hamblin MR and Mirzaei H and Mirzaei HR}, title = {Dysregulated Expression of Mirnas in Immune Thrombocytopenia}, journal = {Epigenomics}, volume = {13}, number = {16}, pages = {1315-1325}, year = {2021} }
RIS	TY - JOUR AU - Jafarzadeh A AU - Marzban H AU - Nemati M AU - Jafarzadeh S AU - Mahjoubintehran M AU - Hamblin MR AU - Mirzaei H AU - Mirzaei HR TI - Dysregulated Expression of Mirnas in Immune Thrombocytopenia JO - Epigenomics VL - 13 IS - 16 SP - 1315 EP - 1325 PY - 2021 ER -

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