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Unfolded Protein Response-Mediated Modulation of Mesenchymal Stem Cells Publisher Pubmed



Tavasolian F1, 2 ; Hosseini AZ1 ; Mirzaei A3, 4 ; Abdollahi E5, 6, 7 ; Jandaghi P8 ; Soudi S1 ; Naderi M9 ; Saburi E10, 11 ; Momtaziborojeni AA5, 12 ; Johnston TP13 ; Sahebkar A14, 15, 16
Authors
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Authors Affiliations
  1. 1. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Department of Human Genetics, McGill University, Montreal, QC, Canada
  3. 3. Cellular & Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  4. 4. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  5. 5. Halal Research Center of IRI, FDA, Tehran, Iran
  6. 6. Department of Medical Immunology and Allergy, Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Mater Research Institute, University of Queensland, Brisbane, Australia
  8. 8. McGill University, Montreal, QC, Canada
  9. 9. Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Clinical Research Development Center, Imam Hasan Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran
  11. 11. Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Nanotechnology Research Center, Department of Medical Biotechnology, Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  13. 13. Division of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, United States
  14. 14. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  15. 15. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  16. 16. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: IUBMB Life Published:2020


Abstract

The endoplasmic reticulum (ER) receives unfolded proteins predestined for the secretory pathway or to be incorporated as transmembrane proteins. The ER has to accommodate the proper folding and glycosylation of these proteins and also to properly incorporate transmembrane proteins. However, under various circumstances, the proteins shuttling through the ER can be misfolded and undergo aggregation, which causes activation of the unfolded protein response (UPR). The UPR is mediated through three primary pathways: activating transcription factor-6, inositol-requiring enzyme-1 (IRE1), and PKR-like endoplasmic reticulum kinase, which up-regulate ER folding chaperones and temporarily suppress protein translation. The UPR can be both cytoprotective and/or cytotoxic depending on the duration of UPR activation and the type of host cell. Proteostasis controls stem cell function, while stress responses affect stem cell identity and differentiation. The present review aimed to explore and discuss the effects of the UPR pathways on mesenchymal stem cells. © 2019 International Union of Biochemistry and Molecular Biology
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