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Dishevelled: An Emerging Therapeutic Oncogene in Human Cancers Publisher Pubmed



Alshahrani SH1 ; Rakhimov N2, 3 ; Rana A4 ; Alsaab HO5 ; Hjazi A6 ; Adile M7 ; Abosaooda M8 ; Abdulhussien Alazbjee AA9 ; Alsalamy A10 ; Mahmoudi R11
Authors
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Authors Affiliations
  1. 1. Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia
  2. 2. Department of Oncology, Samarkand State Medical University, Amir Temur Street 18, Samarkand, Uzbekistan
  3. 3. Department of Scientific Affairs, Tashkent State Dental Institute, Makhtumkuli 103, Tashkent, Uzbekistan
  4. 4. Uttaranchal Institute of Technology, Uttaranchal University, Dehradun, 248007, India
  5. 5. Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia
  6. 6. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  7. 7. Medical Technical College, Al-Farahidi University, Baghdad, Iraq
  8. 8. College of Pharmacy, The Islamic University, Najaf, 54001, Iraq
  9. 9. College of Medicine, Al-Ayen University, Thi-Qar, Iraq
  10. 10. College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, 66002, Iraq
  11. 11. Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Cancer is a multifaceted and complex disorder characterized by uncontrolled rates of cell proliferation and its ability to spread and attack other organs. Emerging data indicated several pathways and molecular targets are engaged in cancer progression. Among them, the Wnt signaling pathway was shown to have a crucial role in cancer onset and progression. Dishevelled (DVL) acts in a branch point of canonical and non-canonical Wnt pathway. DVL not only acts in the cytoplasm to inactivate the destruction complex of β-catenin but is also transported into the nucleus to affect the transcription of target genes. Available data revealed that the expression levels of DVL increased in cell and clinical specimens of various cancers, proposing that it may have an oncogenic role. DVL promoted cell invasion, migration, cell cycle, survival, proliferation, 3D-spheroid formation, stemness, and epithelial mesenchymal transition (EMT) and it suppressed cell apoptosis. The higher levels of DVL is associated with the clinicopathological characteristic of cancer-affected patients, including lymph node metastasis, tumor grade, histological type, and age. In addition, the higher levels of DVL could be a promising diagnostic and prognostic biomarker in cancer as well as it could be a mediator in cancer chemoresistance to Methotrexate, paclitaxel, and 5-fluorouracil. This study aimed to investigate the underlying molecular mechanism of DVL in cancer pathogenesis as well as to explore its importance in cancer diagnosis and prognosis as well as its role as a mediator in cancer chemotherapy. © 2023 Elsevier GmbH
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