Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis

Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis Publisher Pubmed

Mokhtari Y¹ ; Pourbagherisigaroodi A¹ ; Zafari P^{2, 3} ; Bagheri N⁴ ; Ghaffari SH⁵ ; Bashash D¹

Show Affiliations

1. Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3. Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
5. Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular and Molecular Medicine Published:2021

Abstract

In the dark path of tumorigenesis, the more carefully the cancer biology is studied, the more brilliant answers could be given to the countless questions about its orchestrating derivers. The identification of the correlation between Toll-like receptors (TLRs) and different processes involved in carcinogenesis was one of the single points of blinding light highlighting the interconnection between the immune system and cancer. TLRs are a wide family of single-pass membrane-spanning receptors that have developed through the evolution to recognize the structurally conserved molecules derived from microorganisms or damaged cells. But this is not everything about these receptors as they could orchestrate several downstream signalling pathways leading to the formation or suppression of cancer cells. The present review is tempted to provide a concise schematic about the biology and the characters of TLRs and also summarize the major findings of the regulatory role of TLRs and their associated signalling in the pathogenesis of human cancers. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd

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Style	Citing Format
MLA	Mokhtari Y, et al.. "Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis." Journal of Cellular and Molecular Medicine, vol. 25, no. 2, 2021, pp. 639-651.
APA	Mokhtari Y, Pourbagherisigaroodi A, Zafari P, Bagheri N, Ghaffari SH, Bashash D (2021). Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis. Journal of Cellular and Molecular Medicine, 25(2), 639-651.
Chicago	Mokhtari Y, Pourbagherisigaroodi A, Zafari P, Bagheri N, Ghaffari SH, Bashash D. "Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis." Journal of Cellular and Molecular Medicine 25, no. 2 (2021): 639-651.
Harvard	Mokhtari Y et al. (2021) 'Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis', Journal of Cellular and Molecular Medicine, 25(2), pp. 639-651.
Vancouver	Mokhtari Y, Pourbagherisigaroodi A, Zafari P, Bagheri N, Ghaffari SH, Bashash D. Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis. Journal of Cellular and Molecular Medicine. 2021;25(2):639-651.
BibTex	@article{ author = {Mokhtari Y and Pourbagherisigaroodi A and Zafari P and Bagheri N and Ghaffari SH and Bashash D}, title = {Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis}, journal = {Journal of Cellular and Molecular Medicine}, volume = {25}, number = {2}, pages = {639-651}, year = {2021} }
RIS	TY - JOUR AU - Mokhtari Y AU - Pourbagherisigaroodi A AU - Zafari P AU - Bagheri N AU - Ghaffari SH AU - Bashash D TI - Toll-Like Receptors (Tlrs): An Old Family of Immune Receptors With a New Face in Cancer Pathogenesis JO - Journal of Cellular and Molecular Medicine VL - 25 IS - 2 SP - 639 EP - 651 PY - 2021 ER -

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