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Comparison of Astrazeneca and Sinopharm Vaccines As Boosters in Protection Against Covid-19 Infection Publisher Pubmed



Letafati A1 ; Eyvazzadeh N2 ; Gharehkhani A3 ; Khorshidian A4 ; Chalabiani S5 ; Soufiani EK3 ; Khakpoor N6 ; Shamsodini B7 ; Beheshti T8 ; Bavili Olyaei RT9 ; Soleimani A10 ; Melyani F11 ; Hossein GM12
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Bacteriology, Faculty of Medicine, Qazvin University of Medical Science, Qazvin, Iran
  3. 3. Department of Medical Laboratory Science, Faculty of Para Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
  4. 4. Department of Biology, Faculty of Basic Sciences, Gonbad Kavous University, Gonbad Kavous, Iran
  5. 5. Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University of Qom, Qom, Iran
  6. 6. Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University of Shahrekord, Shahrekord, Iran
  8. 8. Department of Genetics, Faculty of Advanced Sciences and Technology, Islamic Azad University of Tehran, Tehran, Iran
  9. 9. Department of Medical Laboratory Science, Faculty of Medical Sciences, Islamic Azad University, Tabriz Medical Branch, Tabriz, Iran
  10. 10. Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Sarab University, Sarab, Iran
  11. 11. Department of Medical Laboratory Sciences, Faculty of Para Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  12. 12. Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University of Arak, Arak, Iran

Source: Biologicals Published:2023


Abstract

Background: As the global number of confirmed cases rises past 640 million, vaccination remains the most effective measure in controlling COVID-19. Studies have shown that two doses of vaccination can significantly reduce hospitalization and mortality rates among patients, but the effectiveness of booster doses is also important. We aimed to evaluate the role played by the type of the 3rd dose of vaccination by comparing the safety and efficacy of two common vaccination histories differing only in the 3rd received dose. Methods: We conducted a cross-sectional study on patients with respiratory symptoms suspected of having SARS-CoV-2 infection using Real-time PCR. We also collected information on the age, gender, and type of vaccine received for the third dose. Results: Out of 346 cases with respiratory symptoms, 120 cases tested positive for SARS-CoV-2 and had received two doses of Sinopharm and a different booster dose of either AZD1222 (AstraZeneca) or BIBP (Sinopharm). Among these 120 patients, vaccination with AZD1222 as a booster dose resulted in fewer symptoms compared to those vaccinated with three doses of BIBP. Conclusions: Our study demonstrates that booster doses can help reduce hospitalization and the severity of infection, and it appears that a combination of different vaccines may be effective against severe COVID-19 infection. © 2023 International Alliance for Biological Standardization
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