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Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones Publisher



Mohammadhosseini N1 ; Saeedi M2, 3 ; Moradi S1 ; Mahdavi M5 ; Firuzi O4 ; Foroumadi A5 ; Shafiee A5
Authors

Source: Turkish Journal of Chemistry Published:2017


Abstract

Various thioxo-quinazolino[3,4-a]quinazolinones were prepared and evaluated for their cytotoxicity in MOLT-4 (lymphoblastic leukemia) and MCF-7 (breast adenocarcinoma) cell lines. Synthesis of the target compounds was started from isatoic anhydride. Successive reaction of isatoic anhydride with benzylamine and 2-nitrobenzaldehyde, reduction of the nitro group, and reaction with CS2 gave 12-benzyl-6-thioxo-6,7,11b,12-tetrahydro-13H-quinazolino[3,4-a]quinazolin-13-one. The latter compound reacted with various 2-chloro-N-substituted acetamides to afford the corresponding fused quinazolinone derivatives. © TUBITAK.
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