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Aptamer-Functionalized Chitosan-Coated Gold Nanoparticle Complex As a Suitable Targeted Drug Carrier for Improved Breast Cancer Treatment Publisher



Shahidi M1 ; Abazari O1 ; Dayati P2 ; Bakhshi A1 ; Rasti A3 ; Haghiralsadat F4 ; Naghib SM5 ; Tofighi D6
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  5. 5. Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology, Tehran, Iran
  6. 6. Department of Psychology, Epidemiology and Research Design Support (BERD), Clinical and Translational Science Center, University of New Mexico, Albuquerque, NM, United States

Source: Nanotechnology Reviews Published:2022


Abstract

In the following research, we specifically assessed the feasibility of a novel AS-1411-chitosan (CS)-gold nanoparticle (AuNPs) delivery system to carry methotrexate (MTX) into the cancer cells. The designed system had a spherical shape with average size of 62 ± 2.4 nm, the zeta potential of -32.1 ± 1.4 mV, and released MTX in a controlled pH- and time-dependent manner. CS-AuNPs could successfully penetrate the breast cancer cells and release the therapeutic drug, and ultimately, be accumulated by the nucleolin-AS1411 targeting mechanism within the in vivo environment. The anticancer activity of MTX was attributed to the induction of mitochondria membrane potential loss and nuclear fragmentation, which leads to apoptotic death. Moreover, the cellular internalization confirmed the high potential in the elimination of cancer cells without notable cytotoxicity on non-target cells. Therefore, it was concluded that the AS1411-CS-AuNPs with considerable in vitro and in vivo results could be utilized as a favorable system for breast cancer treatment. © 2022 Maryamsadat Shahidi et al., published by De Gruyter.
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