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Multifunctional Mil-Cur@Fc As a Theranostic Agent for Magnetic Resonance Imaging and Targeting Drug Delivery: In Vitro and In Vivo Study Publisher Pubmed



Dehghani S1, 2 ; Hosseini M3 ; Haghgoo S4 ; Changizi V2 ; Akbari Javar H5 ; Khoobi M6 ; Riahi Alam N1
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Radiation Sciences Department, School of Allied Medical Sciences, Health Information Management Research Center, Tehran University of Medical Science, Tehran, Iran
  3. 3. Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  4. 4. Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health, Tehran, Iran
  5. 5. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Drug Targeting Published:2020


Abstract

Owing to the importance of multifunctional theranostics as promising systems to overcome key problems of conventional cancer therapy, in this study a multifunctional metal–organic framework-based (MOF) theranostic system was prepared and applied as intelligent theranostic systems in cancer. Iron-based MOF, MIL-88B, in a multi-faceted shape was initially prepared. Curcumin (Cur) was then loaded into the pores of MIL and folic acid–chitosan conjugate (FC) was finally coated on the surface of the carrier to accomplish cancer-specific targeting properties. MTT assay revealed perfect cytocompatibility of the system and selective toxicity against cancerous cells. In vivo MRI images showed high tumour uptake for MIL-Cur@FC and high T1–T2 contrast effect. The growth inhibiting efficiencies of MIL-Cur@FC on M109 tumour bearing Balb/C mice without reducing their body weight showed maximum tumour eradication with no significant toxicities. Due to the outstanding features of the system achieved from in vitro and in vivo studies, we believe that this study will provide a novel approach for developing targeted theranostic agents in cancer diagnosis and treatment. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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