Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo

Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo Publisher

Abtahi NA^{1, 2} ; Salehi S¹ ; Naghib SM¹ ; Haghiralsadat F³ ; Edgahi MA¹ ; Ghorbanzadeh S⁴ ; Zhang W⁴

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1. Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology, Tehran, Iran
2. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
3. Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4. State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China

Source: Cancer Nanotechnology Published:2023

Abstract

MicroRNAs, which can contribute to numerous cellular functions through post-transcriptional silencing, have become well-documented candidates for cancer treatment applications, particularly in chemo-resistant cancers. Herein, several formulations were examined to optimize the essential parameters, and the niosomal formulation consisting of cholesterol:tween-80:DOTAP:PEG with 9:69:15:7 ratio had the best physicochemical parameters including spherical shape, high entrapment efficiency, small diameter (81 ± 0.65 nm), and appropriate positive charge (23 ± 0.64 mV). Here, we aimed to design a system with increased delivery efficiency which was tested by the encapsulation of miR-34a within niosome NPs and assessed the nano-niosomal delivery of miR-34a as a tumor suppressor in MCF-7 human adenocarcinoma cells. The results showed that our novel niosome systems with non-ionic surfactants can successfully eliminate cancer cells by increasing the expression of p53 and reducing the expression of NF-κB. In comparison with the free dispersion of miR-34a, the lysis of a nano-sized delivery system demonstrated a better cytotoxicity effect against cancer cells. Similar results were obtained by performing in vivo test on the 4T1 xenografted Balb/C mouse tumor model and the miR-34a-loaded niosomes displayed a better reduction in tumor size by improving approximately + 13% in tumor inhabitation rate while maintaining the bodyweight close to the first day. Therefore, it is concluded that miR-34a delivery via niosomes has high potential as a tumor suppressor and a reliable procedure for breast cancer treatment. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).

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Hamid Reza Mirzaei (1)

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Style	Citing Format
MLA	Abtahi NA, et al.. "Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo." Cancer Nanotechnology, vol. 14, no. 1, 2023, pp. -.
APA	Abtahi NA, Salehi S, Naghib SM, Haghiralsadat F, Edgahi MA, Ghorbanzadeh S, Zhang W (2023). Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo. Cancer Nanotechnology, 14(1), -.
Chicago	Abtahi NA, Salehi S, Naghib SM, Haghiralsadat F, Edgahi MA, Ghorbanzadeh S, Zhang W. "Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo." Cancer Nanotechnology 14, no. 1 (2023): -.
Harvard	Abtahi NA et al. (2023) 'Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo', Cancer Nanotechnology, 14(1), pp. -.
Vancouver	Abtahi NA, Salehi S, Naghib SM, Haghiralsadat F, Edgahi MA, Ghorbanzadeh S, et al.. Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo. Cancer Nanotechnology. 2023;14(1):-.
BibTex	@article{ author = {Abtahi NA and Salehi S and Naghib SM and Haghiralsadat F and Edgahi MA and Ghorbanzadeh S and Zhang W}, title = {Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo}, journal = {Cancer Nanotechnology}, volume = {14}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Abtahi NA AU - Salehi S AU - Naghib SM AU - Haghiralsadat F AU - Edgahi MA AU - Ghorbanzadeh S AU - Zhang W TI - Multi-Sensitive Functionalized Niosomal Nanocarriers for Controllable Gene Delivery in Vitro and in Vivo JO - Cancer Nanotechnology VL - 14 IS - 1 SP - EP - PY - 2023 ER -

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