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Targeted Drug Delivery Based on Gold Nanoparticle Derivatives Publisher Pubmed



Gholipourmalekabadi M1, 2, 3 ; Mobaraki M4 ; Ghaffari M4 ; Zarebkohan A5 ; Omrani VF3 ; Urbanska AM6 ; Seifalian A7
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Faculty of Advanced, Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Biomaterials Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  5. 5. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center, Columbia University, New York, NY, United States
  7. 7. Nanotechnology & Regenerative Medicine Commercialization Centre (Ltd), The London BioScience Innovation Centre, London, United Kingdom

Source: Current Pharmaceutical Design Published:2017


Abstract

Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surface modifications of AuNPs profoundly improve their circulation, minimize aggregation rates, enhance attachment to therapeutic molecules and target agents due to their nano range size which further increases their ability to cross cell membranes and reduce overall cytotoxicity. This comprehensive article reviews the applications of the AuNPs in drug delivery systems along with their corresponding surface modifications. The highlighting results obtained from the preclinical trial are promising and next five years have huge possibility move to the clinical setting. © 2017 Bentham Science Publishers.
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